Detailed information of TA system TA226305

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): AbkB-shpB/BrnT-BrnA
• Location: 1044070..1044622
• Replicon: chromosome
• Accession: NZ_CP087830
• Organism: Moraxella bovis strain SAM102599

Toxin (Protein)

• Gene name: AbkB
• Uniprot ID: A0A1T0A7D3
• Locus tag: LP092_RS05445
• Protein ID: WP_029102268.1
• Coordinates: 1044344..1044622 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: -
• Locus tag: LP092_RS05440
• Protein ID: WP_078273473.1
• Coordinates: 1044070..1044357 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP092_RS05420 (LP092_05390)	1039505..1040554	+	1050	WP_264683526.1	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	-
LP092_RS05425 (LP092_05395)	1040633..1042132	+	1500	WP_112742120.1	DUF389 domain-containing protein	-
LP092_RS05430	1042161..1042286	+	126	WP_264676709.1	hypothetical protein	-
LP092_RS05435 (LP092_05400)	1042330..1044060	-	1731	WP_078273474.1	flotillin domain-containing protein	-
LP092_RS05440 (LP092_05405)	1044070..1044357	-	288	WP_078273473.1	BrnA antitoxin family protein	Antitoxin
LP092_RS05445 (LP092_05410)	1044344..1044622	-	279	WP_029102268.1	BrnT family toxin	Toxin
LP092_RS05450 (LP092_05415)	1044717..1045373	-	657	WP_078273472.1	YqiJ family protein	-
LP092_RS05455 (LP092_05420)	1045573..1046238	-	666	WP_078273471.1	PspA/IM30 family protein	-
LP092_RS05460 (LP092_05425)	1046451..1046741	-	291	WP_264676229.1	hypothetical protein	-
LP092_RS05465 (LP092_05430)	1046734..1047249	-	516	WP_115369660.1	hypothetical protein	-
LP092_RS05470 (LP092_05435)	1047397..1047747	-	351	WP_078273468.1	TIGR01244 family sulfur transferase	-
LP092_RS05475 (LP092_05440)	1047859..1048635	+	777	WP_264676230.1	nucleotidyltransferase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-85)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (36-89)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10484.81 Da
• Isoelectric Point: 5.1084

>T226305 WP_029102268.1 NZ_CP087830:c1044622-1044344 [Moraxella bovis]
MIFEWDDNKNRTNKQKHGVSFESASRIFLDPFLIVTEDTSSDEVRWLGVGSVDGVVILLVVHTHTDTDGTEIIRIISARK
LSRGEIERYGYC

Nucleotide

• Length: 279 bp

>T226305 NZ_CP122407:3936673-3936954 [Rugamonas sp. DEMB1]
ATGACCATCCGTTCCTTCCGTTGCAAAGATACGAAGGCGCTGTATGCCGGTGGCAAGGTCGGAAAATTCGCGAACGTCCG
CTCCACGGCCGAACGCAAGCTTCAACTGCTCGATAGCGCCGCCAGCCTCGATTTCTTGCGCACGCCGCCAGGCAACCACT
TGGAGGCACTCGGCGCCGATCGCAAAGGACAGTACAGCATCCGGATTAACAATCAGTTCAGAATCTGCTTCGTCTGGACC
TCGGCGGGTCCCGAAGACGTCGAAATCGTCGACTACCACTAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10979.71 Da
• Isoelectric Point: 7.0097

>AT226305 WP_078273473.1 NZ_CP087830:c1044357-1044070 [Moraxella bovis]
MAIVRKTLDDIKHTPIDKDELAQLQSMSDDSINYDDIPPLTDVQIANLRLYKPIKQQITLRLDSDIVAWLKKDGKGYQTR
ANQLLRQLMLKELTT

Nucleotide

• Length: 288 bp

>AT226305 NZ_CP122407:3936974-3937303 [Rugamonas sp. DEMB1]
ATGGCAGAGAACCAAATGCGTCCGATCCATCCCGGCGAGATTCTGCGCGAGGAATTCCTGGCGCCGCTGGCGATGACGCC
GCACGCGCTGTCCAAGGCGTTGCATGTGACGCCGGCGCGCATCAACGACATCGTCAACGAAAAACGCGGCGTCAGCGCCG
ACACCGCGCTACGCCTGGCGCGCTACTTCGGCGGCGAGCCACAGTCCTGGCTCAACCTACAACAGGCGTACGACCTCAAA
ATGGCCACCCGCGCCGGCCTGGAGAGGATCCTCGTCGAGGTCCGGCCGCGCGCCCCCGGCGACGGTGACGAGGCCGCGCT
GGCGGCGTGA

Structures

Toxin

• AlphaFold DB: A0A1T0A7D3