Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 717942..718591 Replicon chromosome
Accession NZ_CP087830
Organism Moraxella bovis strain SAM102599

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP092_RS03625 Protein ID WP_078274052.1
Coordinates 718190..718591 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP092_RS03620 Protein ID WP_112741908.1
Coordinates 717942..718175 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP092_RS03600 (LP092_03585) 713338..713787 - 450 WP_264676133.1 cytochrome c -
LP092_RS03605 (LP092_03590) 713969..714961 - 993 WP_078274055.1 oxygen-dependent coproporphyrinogen oxidase -
LP092_RS03610 (LP092_03595) 714981..715574 - 594 WP_208624078.1 GTP cyclohydrolase II -
LP092_RS03615 (LP092_03600) 715795..717894 + 2100 WP_078274054.1 1-deoxy-D-xylulose-5-phosphate synthase -
LP092_RS03620 (LP092_03605) 717942..718175 + 234 WP_112741908.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP092_RS03625 (LP092_03610) 718190..718591 + 402 WP_078274052.1 type II toxin-antitoxin system VapC family toxin Toxin
LP092_RS03630 (LP092_03615) 719115..719615 + 501 WP_112741909.1 WG repeat-containing protein -
LP092_RS03635 (LP092_03620) 719737..720567 + 831 WP_078274050.1 inositol monophosphatase family protein -
LP092_RS03640 (LP092_03625) 720666..721355 - 690 WP_078274049.1 SIMPL domain-containing protein -
LP092_RS03650 (LP092_03635) 722091..722510 - 420 WP_078274047.1 S4 domain-containing protein -
LP092_RS03655 (LP092_03640) 722507..722683 - 177 WP_228157829.1 ASCH domain-containing protein -
LP092_RS03660 (LP092_03645) 722702..722935 - 234 WP_112741910.1 ASCH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15131.33 Da        Isoelectric Point: 6.8510

>T226302 WP_078274052.1 NZ_CP087830:718190-718591 [Moraxella bovis]
MFSFMLDTNIYIYVIKERPIKALNKFNQYAGRICVSSIVASELYFGAYNSQFMDKNLHQVEDFLSRLTVLDYTAECSPHY
GEICADLTKQGKLISENDIHIASHARALGLTLITNNTDEFKRVSGLRIGNWAI

Download         Length: 402 bp

>T226302 NZ_CP122407:c2078793-2078515 [Rugamonas sp. DEMB1]
ATGATAATTTCATTCGCATGCTCCGAAACGGAAGCACTGTTCAACAGCCTCAGTGTTCGCCACTTCAAGAATATTGAGCG
GTCAGCCCGGCGCAAGTTGCTTCAGTTGAATGCCGCTGGCGAGTTGAGAAGCTTGCGCATCCCTCCCGGAAACATGTTGG
AGGCATTGAGCGGAAGCCGCAAAGGCCAGTACAGCATACGAATCAACGACCAATGGCGTATCTGCTTCAAATGGCAAGCG
GATGGGCCGCATGACGTGGAAATTGTGGATTACCACTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8990.22 Da        Isoelectric Point: 6.2884

>AT226302 WP_112741908.1 NZ_CP087830:717942-718175 [Moraxella bovis]
MQTSVFFNNRTQAVRIPAKFRFDDDVKAVMIRKVGNERILTPIDGVWDSFFLSDERASDDFMANRPTMPKSERLTFD

Download         Length: 234 bp

>AT226302 NZ_CP122407:c2078491-2078183 [Rugamonas sp. DEMB1]
ATGGCCAAATTACTCGATGAAGTACATCCCGGCGAAATCCTGCTGGAAGAGTTCATGCGGCCGCTGGGCATCACCGCACA
GCAGTTGGCCGCCGATATCGACGTCTCGCCCAGCCGCATCAGCGACATCGTGCATGGCAATCGCCCCATCACGGCGGATA
CGGCGCTACGCCTTGGCCTATTTTTCGACATGGAGGCCAGGTATTGGCTGAACCTGCAAAGCGAGTACGACATGCGCATC
GCGCAACGTACCTTGAAAGATCAATTGGCTCCCCGCATACGGGTGTACCAGCCTGTCCGCCCAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References