Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2268672..2269330 Replicon chromosome
Accession NZ_CP087828
Organism Moraxella bovis strain SAM102600

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP099_RS11540 Protein ID WP_078274940.1
Coordinates 2269142..2269330 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP099_RS11535 Protein ID WP_112741846.1
Coordinates 2268672..2269079 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP099_RS11505 (LP099_11405) 2263903..2265732 - 1830 WP_078274936.1 hypothetical protein -
LP099_RS11510 (LP099_11410) 2265720..2266064 - 345 WP_078274937.1 hypothetical protein -
LP099_RS11515 (LP099_11415) 2266065..2266871 - 807 WP_264684230.1 hypothetical protein -
LP099_RS11520 (LP099_11420) 2266925..2267362 - 438 WP_162860346.1 hypothetical protein -
LP099_RS11525 (LP099_11425) 2267296..2267628 - 333 WP_112741848.1 hypothetical protein -
LP099_RS11530 (LP099_11430) 2267625..2268596 - 972 WP_112741847.1 phage tail tape measure protein -
LP099_RS11535 (LP099_11435) 2268672..2269079 - 408 WP_112741846.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP099_RS11540 (LP099_11440) 2269142..2269330 - 189 WP_078274940.1 type II toxin-antitoxin system HicA family toxin Toxin
LP099_RS11545 (LP099_11445) 2269473..2269688 - 216 WP_078274941.1 hypothetical protein -
LP099_RS11550 (LP099_11450) 2269690..2270289 - 600 WP_078274942.1 antA/AntB antirepressor family protein -
LP099_RS11555 (LP099_11455) 2270396..2270602 - 207 WP_264676102.1 DNA-binding protein -
LP099_RS11560 (LP099_11460) 2270769..2271068 + 300 WP_264690283.1 helix-turn-helix transcriptional regulator -
LP099_RS11565 (LP099_11465) 2271112..2271864 - 753 WP_078274945.1 hypothetical protein -
LP099_RS11570 (LP099_11470) 2271942..2272142 - 201 WP_264676324.1 hypothetical protein -
LP099_RS11575 (LP099_11475) 2272151..2272342 - 192 WP_264676101.1 DNA-binding protein -
LP099_RS11580 (LP099_11480) 2272357..2272566 - 210 WP_078274960.1 hypothetical protein -
LP099_RS11585 (LP099_11485) 2272731..2273030 + 300 WP_078274961.1 helix-turn-helix transcriptional regulator -
LP099_RS11590 (LP099_11490) 2273225..2273512 + 288 WP_078274962.1 ORF6C domain-containing protein -
LP099_RS11595 (LP099_11495) 2273509..2273928 + 420 WP_112741841.1 S24 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2267625..2273928 6303


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-130)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7047.13 Da        Isoelectric Point: 10.3659

>T226301 WP_078274940.1 NZ_CP087828:c2269330-2269142 [Moraxella bovis]
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD

Download         Length: 189 bp

>T226301 NZ_CP122407:1810983-1811258 [Rugamonas sp. DEMB1]
GTGGAGTTGCGGTGGACCAAGAAGTCGCTATCCGATTTGACGCGATTGCACGAGTTCTTGGCGGCGGTGAATGAGCCAGC
GGCGGCCCGCACGGTGCAATCGCTCACAGCCGCAGCGGCCAGTTTGCTGGAAAATCCACGTATTGGAGAGCGCTTGGAAG
AATTCGAGCCACGCGAAATCCGGCGAATTCTCGTTGGCCGTTATGAGCTGCGCTACGAAATCAAGGCATCAACAATTTAC
ATCATGCGCTTGTGGCATACGCGCGAGGACCGTTAG

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14756.85 Da        Isoelectric Point: 4.2244

>AT226301 WP_112741846.1 NZ_CP087828:c2269079-2268672 [Moraxella bovis]
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG

Download         Length: 408 bp

>AT226301 NZ_CP122407:1810507-1810983 [Rugamonas sp. DEMB1]
GTGAAAATTGCCCCTCCTCTTAGGCGGCGCGTGCAAGGGAATGCGCTATCGCGAAGATATGCGTGTGAAAATTATCATCC
AGAATATTCTCTCGACACCGACACCGACACCGACACCGACACCGACACCGACACCGACACCGACACCGACAACGACAACG
CACTCGCGCACTTCGAAAAAGCCAATTTGAAGGGATCATTTATGGCACACACAGAAACAAAAGTGTTTACCGCACATGTA
CCTGTAGCGCTGGCCGAAAAGGTCGACCAGCTAGCCTCCCGCCTTGAACGTTCGCGTGGCTGGATCGTCAAACAAGCGCT
GAGCGCTTGGGTTGACCTCGAAGAGGAGAGGAGCCGGCTCACGCGTGAAGCGATGGCCGACGTGGAGGCCGGGCATGTCA
TCGATCACCAGTCGGTACAGGCTTGGGCCGATAGCCTCGGCACCGAGAACCCGCTGCCCGCGCCTGTGGTGCCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References