Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2108291..2108940 Replicon chromosome
Accession NZ_CP087828
Organism Moraxella bovis strain SAM102600

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP099_RS10730 Protein ID WP_078274052.1
Coordinates 2108291..2108692 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP099_RS10735 Protein ID WP_112741908.1
Coordinates 2108707..2108940 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP099_RS10695 (LP099_10595) 2103947..2104180 + 234 WP_112741910.1 ASCH domain-containing protein -
LP099_RS10700 (LP099_10600) 2104226..2104375 + 150 WP_162860355.1 hypothetical protein -
LP099_RS10705 (LP099_10605) 2104372..2104791 + 420 WP_078274047.1 S4 domain-containing protein -
LP099_RS10715 (LP099_10615) 2105527..2106216 + 690 WP_078274049.1 SIMPL domain-containing protein -
LP099_RS10720 (LP099_10620) 2106315..2107145 - 831 WP_078274050.1 inositol monophosphatase family protein -
LP099_RS10725 (LP099_10625) 2107267..2107767 - 501 WP_112741909.1 WG repeat-containing protein -
LP099_RS10730 (LP099_10630) 2108291..2108692 - 402 WP_078274052.1 type II toxin-antitoxin system VapC family toxin Toxin
LP099_RS10735 (LP099_10635) 2108707..2108940 - 234 WP_112741908.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP099_RS10740 (LP099_10640) 2108988..2111087 - 2100 WP_078274054.1 1-deoxy-D-xylulose-5-phosphate synthase -
LP099_RS10745 (LP099_10645) 2111308..2111901 + 594 WP_208624078.1 GTP cyclohydrolase II -
LP099_RS10750 (LP099_10650) 2111921..2112913 + 993 WP_078274055.1 oxygen-dependent coproporphyrinogen oxidase -
LP099_RS10755 (LP099_10655) 2113095..2113544 + 450 WP_264676133.1 cytochrome c -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15131.33 Da        Isoelectric Point: 6.8510

>T226300 WP_078274052.1 NZ_CP087828:c2108692-2108291 [Moraxella bovis]
MFSFMLDTNIYIYVIKERPIKALNKFNQYAGRICVSSIVASELYFGAYNSQFMDKNLHQVEDFLSRLTVLDYTAECSPHY
GEICADLTKQGKLISENDIHIASHARALGLTLITNNTDEFKRVSGLRIGNWAI

Download         Length: 402 bp

>T226300 NZ_CP122407:738280-738567 [Rugamonas sp. DEMB1]
ATGCTCCCTGTTCAATGGCTTGCCAAGGCCAACATCAACTTGGCTACCATCATCACGTATATTGCCGAGCGCAATGATGT
TGCGGCTTCCGAGTTGCAGAATGACATTGAGCGCGCCGTATCGCAACTGCCGCAGCACCCCTACCTGTACCGCCCCGGCC
GTGTCGCTGGCACGCGGGAGATCGTGGTGCACGCCAACTACGTGGTCGTGTATCGCGTCCTGCCAACCGTGATTGAGATT
GTCGCGGTCCTGCACACGCGCCAGCAATACCCAGCCGCCGCGAAGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8990.22 Da        Isoelectric Point: 6.2884

>AT226300 WP_112741908.1 NZ_CP087828:c2108940-2108707 [Moraxella bovis]
MQTSVFFNNRTQAVRIPAKFRFDDDVKAVMIRKVGNERILTPIDGVWDSFFLSDERASDDFMANRPTMPKSERLTFD

Download         Length: 234 bp

>AT226300 NZ_CP122407:738032-738232 [Rugamonas sp. DEMB1]
ATGAACACCGTCCTATCCCCAATCGAATCCGAGTTCGCCACCGCCGAAGAGGCTGCGGCGTATGATCGTTGGTTCCGCGC
CCAGGTGCAGGAGTCCATTGATGACTCGCGCCCCAGCATCCCGCATGATCAGGTGATGGCCGAAATGCGGGCCATCATCG
CGTCAAAACGGAAAAATGCTGGGTCGAATAGCTCGTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References