Detailed information of TA system TA226297

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): AbkB-shpB/BrnT-BrnA
• Location: 1781180..1781732
• Replicon: chromosome
• Accession: NZ_CP087828
• Organism: Moraxella bovis strain SAM102600

Toxin (Protein)

• Gene name: AbkB
• Uniprot ID: A0A1T0A7D3
• Locus tag: LP099_RS08890
• Protein ID: WP_029102268.1
• Coordinates: 1781180..1781458 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: -
• Locus tag: LP099_RS08895
• Protein ID: WP_078273473.1
• Coordinates: 1781445..1781732 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP099_RS08860 (LP099_08780)	1777167..1777943	-	777	WP_078273467.1	nucleotidyltransferase domain-containing protein	-
LP099_RS08865 (LP099_08785)	1778055..1778405	+	351	WP_078273468.1	TIGR01244 family sulfur transferase	-
LP099_RS08870 (LP099_08790)	1778553..1779068	+	516	WP_078273469.1	hypothetical protein	-
LP099_RS08875 (LP099_08795)	1779169..1779351	+	183	WP_264683628.1	hypothetical protein	-
LP099_RS08880 (LP099_08800)	1779564..1780229	+	666	WP_078273471.1	PspA/IM30 family protein	-
LP099_RS08885 (LP099_08805)	1780429..1781085	+	657	WP_078273472.1	YqiJ family protein	-
LP099_RS08890 (LP099_08810)	1781180..1781458	+	279	WP_029102268.1	BrnT family toxin	Toxin
LP099_RS08895 (LP099_08815)	1781445..1781732	+	288	WP_078273473.1	BrnA antitoxin family protein	Antitoxin
LP099_RS08900 (LP099_08820)	1781742..1783472	+	1731	WP_078273474.1	flotillin domain-containing protein	-
LP099_RS08905	1783516..1783641	-	126	WP_264676709.1	hypothetical protein	-
LP099_RS08910 (LP099_08825)	1783670..1785169	-	1500	WP_112742120.1	DUF389 domain-containing protein	-
LP099_RS08915 (LP099_08830)	1785248..1786297	-	1050	WP_264683526.1	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-85)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (36-89)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10484.81 Da
• Isoelectric Point: 5.1084

>T226297 WP_029102268.1 NZ_CP087828:1781180-1781458 [Moraxella bovis]
MIFEWDDNKNRTNKQKHGVSFESASRIFLDPFLIVTEDTSSDEVRWLGVGSVDGVVILLVVHTHTDTDGTEIIRIISARK
LSRGEIERYGYC

Nucleotide

• Length: 279 bp

>T226297 NZ_CP122401:2919333-2919620 [Enterobacter roggenkampii]
ATGCATAAATTAACACCTTACGATCCCGCCAACGCGTTGGTGGATGACGAGGAAATCGCCGTGTTTATCGCTGATGCACT
AGAAACAGGCGACTCGACATATATCGCTAAAGCCCTTGGTGTTGTCGCGCGAGCCAAAGGCATGTCGAACATTTCACAGC
AAACCGGTTTATCACGTGAGCAGCTTTATCGGTCATTCAGTGATAAAGGAAACCCAACGCTCAAAACCACGCTCGCGGTC
ATGAAAGCATTGGGTTTTGGGCTAACACTCAAACACGCCGGGGATTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10979.71 Da
• Isoelectric Point: 7.0097

>AT226297 WP_078273473.1 NZ_CP087828:1781445-1781732 [Moraxella bovis]
MAIVRKTLDDIKHTPIDKDELAQLQSMSDDSINYDDIPPLTDVQIANLRLYKPIKQQITLRLDSDIVAWLKKDGKGYQTR
ANQLLRQLMLKELTT

Nucleotide

• Length: 288 bp

>AT226297 NZ_CP122401:2919024-2919326 [Enterobacter roggenkampii]
ATGAAGGAGATTGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAACTTAAAAGATCGACGAGCGAAGACCATTATCGC
TTCCCGCCTCTTTCGGTTGGCAAATGGCTTAGCGGGCGACGTTAAACCCGTGGGAGAAGGTATAAGTGAGCTAAGGATCC
ACTTTGGTCCGGGCTACAGGATCTATTTTAAAGACCAGGGCAATTACATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTGATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Structures

Toxin

• AlphaFold DB: A0A1T0A7D3