Detailed information of TA system TA226296

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 1570292..1570781
• Replicon: chromosome
• Accession: NZ_CP087828
• Organism: Moraxella bovis strain SAM102600

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LP099_RS07655
• Protein ID: WP_264676856.1
• Coordinates: 1570292..1570549 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: LP099_RS07660
• Protein ID: WP_228157840.1
• Coordinates: 1570539..1570781 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP099_RS07635 (LP099_07565)	1565320..1566168	+	849	WP_264676852.1	hypothetical protein	-
LP099_RS07640 (LP099_07570)	1566271..1568757	+	2487	WP_264684011.1	alpha/beta hydrolase	-
LP099_RS07645 (LP099_07575)	1568854..1569657	-	804	WP_264676854.1	UDP-2,3-diacylglucosamine diphosphatase	-
LP099_RS07650 (LP099_07580)	1569724..1570233	-	510	WP_264676855.1	peptidylprolyl isomerase	-
LP099_RS07655 (LP099_07585)	1570292..1570549	-	258	WP_264676856.1	Txe/YoeB family addiction module toxin	Toxin
LP099_RS07660 (LP099_07590)	1570539..1570781	-	243	WP_228157840.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
LP099_RS07665 (LP099_07595)	1570826..1570990	+	165	WP_158079593.1	hypothetical protein	-
LP099_RS07670 (LP099_07600)	1571072..1571359	-	288	WP_115005096.1	DUF1315 family protein	-
LP099_RS07675 (LP099_07605)	1571382..1572329	-	948	WP_264676857.1	DUF853 domain-containing protein	-
LP099_RS07680 (LP099_07610)	1572316..1572732	-	417	WP_264676858.1	DUF853 domain-containing protein	-
LP099_RS07685 (LP099_07615)	1572645..1572902	-	258	WP_264676404.1	DUF853 domain-containing protein	-
LP099_RS07690 (LP099_07620)	1573120..1573551	-	432	WP_264690204.1	bestrophin family protein	-
LP099_RS07695 (LP099_07625)	1573517..1573729	-	213	WP_264676860.1	bestrophin family protein	-
LP099_RS07700 (LP099_07630)	1573726..1574523	-	798	WP_264676861.1	polyphenol oxidase family protein	-
LP099_RS07705 (LP099_07635)	1574642..1575691	-	1050	WP_264689785.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-68)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10488.00 Da
• Isoelectric Point: 8.1158

>T226296 WP_264676856.1 NZ_CP087828:c1570549-1570292 [Moraxella bovis]
MRIRWFDEVWEDYLYWQSQDKKTIKRINTLIKDCRRDPFDGIGKPEPLKYNLTGYWLRRINDANRLVYCCESETLIISCR
HHYEA

Nucleotide

• Length: 258 bp

>T226296 NZ_CP122401:2919024-2919326 [Enterobacter roggenkampii]
ATGAAGGAGATTGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAACTTAAAAGATCGACGAGCGAAGACCATTATCGC
TTCCCGCCTCTTTCGGTTGGCAAATGGCTTAGCGGGCGACGTTAAACCCGTGGGAGAAGGTATAAGTGAGCTAAGGATCC
ACTTTGGTCCGGGCTACAGGATCTATTTTAAAGACCAGGGCAATTACATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTGATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9134.23 Da
• Isoelectric Point: 6.2120

>AT226296 WP_228157840.1 NZ_CP087828:c1570781-1570539 [Moraxella bovis]
MNYSEFRQNLASALDYVQDSHAPVIVKRGKHSAVVISLDEYNAFKETDYLLSNPANAEHLMRGVQAVKNRQLTQRDLIED

Nucleotide

• Length: 243 bp

>AT226296 NZ_CP122401:2919333-2919620 [Enterobacter roggenkampii]
ATGCATAAATTAACACCTTACGATCCCGCCAACGCGTTGGTGGATGACGAGGAAATCGCCGTGTTTATCGCTGATGCACT
AGAAACAGGCGACTCGACATATATCGCTAAAGCCCTTGGTGTTGTCGCGCGAGCCAAAGGCATGTCGAACATTTCACAGC
AAACCGGTTTATCACGTGAGCAGCTTTATCGGTCATTCAGTGATAAAGGAAACCCAACGCTCAAAACCACGCTCGCGGTC
ATGAAAGCATTGGGTTTTGGGCTAACACTCAAACACGCCGGGGATTAA