Detailed information of TA system TA226295

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 431713..432365
• Replicon: chromosome
• Accession: NZ_CP087828
• Organism: Moraxella bovis strain SAM102600

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LP099_RS02175
• Protein ID: WP_078275188.1
• Coordinates: 431973..432365 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LP099_RS02170
• Protein ID: WP_078275189.1
• Coordinates: 431713..431976 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP099_RS02140 (LP099_02125)	427030..428364	+	1335	WP_112741795.1	deoxyguanosinetriphosphate triphosphohydrolase	-
LP099_RS02145 (LP099_02130)	428508..428801	+	294	WP_029103533.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
LP099_RS02150 (LP099_02135)	428794..429066	+	273	WP_228157760.1	type II toxin-antitoxin system YafQ family toxin	-
LP099_RS02155 (LP099_02140)	429131..429571	-	441	WP_208624064.1	type IV secretion protein Rhs	-
LP099_RS02160 (LP099_02145)	429622..430395	+	774	WP_078275191.1	hypothetical protein	-
LP099_RS02165 (LP099_02150)	430374..431633	+	1260	WP_078275190.1	replication-associated recombination protein A	-
LP099_RS02170 (LP099_02155)	431713..431976	+	264	WP_078275189.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
LP099_RS02175 (LP099_02160)	431973..432365	+	393	WP_078275188.1	type II toxin-antitoxin system VapC family toxin	Toxin
LP099_RS02180 (LP099_02165)	432488..433018	+	531	WP_078275187.1	HI_0552 family protein	-
LP099_RS02185 (LP099_02170)	433015..433581	-	567	WP_078275186.1	hypothetical protein	-
LP099_RS02190 (LP099_02175)	433584..433820	-	237	WP_078275185.1	sulfurtransferase TusA	-
LP099_RS02195 (LP099_02180)	433817..434275	-	459	WP_078275184.1	acyl-CoA thioesterase	-
LP099_RS02200 (LP099_02185)	434355..435377	-	1023	WP_078275183.1	hypothetical protein	-
LP099_RS02205 (LP099_02190)	435408..436286	-	879	WP_112741796.1	uroporphyrinogen-III synthase	-
LP099_RS02210 (LP099_02195)	436332..437273	-	942	WP_078275181.1	hydroxymethylbilane synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-122)

Antitoxin

• SpoVT-AbrB domain (10-50)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14689.79 Da
• Isoelectric Point: 4.7370

>T226295 WP_078275188.1 NZ_CP087828:431973-432365 [Moraxella bovis]
MKYLLDTNAVIAILNASERFLTTLERHKEREIAISSIVLSELYYGAYKSQKTAQNLEKINLLPFEVLQFNSQDADKAGEI
GATLERRGTPIGFYDTLIAGQAIANDLIVITDNVREFLRVDGLQIENWLK

Nucleotide

• Length: 393 bp

>T226295 NZ_CP122401:2115702-2115920 [Enterobacter roggenkampii]
ATGTCTGATAAACCACTCACTAAAATCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATTGACACCCTCGAACGCGT
GATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCCGTATTTTATTCAGCCGCTGACCATCGTCTTGCTGAGC
TGACCATGAATAAGTTGTATGACAAAATCCCTACTTCTGTATGGAAATTTGTCCGTTAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10183.52 Da
• Isoelectric Point: 6.3724

>AT226295 WP_078275189.1 NZ_CP087828:431713-431976 [Moraxella bovis]
MRQTATAKLFWTGNSQAVRLPKTFRFEGTEVRIKKQGRQVIIEPAETQDWAWLDKLRAMPKDDSFEEAILEGRQNLKADE
RDWGAFE

Nucleotide

• Length: 264 bp

>AT226295 NZ_CP122401:2115300-2115674 [Enterobacter roggenkampii]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAACCTTGATGAAAGCAACCATGGCTGGGTAAACGACCCAACGTCTGCCATCAATTTACAGTTGAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATTGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGTAGTTACGGCATTAACGCCCAGGATTTGCAAAAATGGCGTAAATCGGGAAACCGGCT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCGGTTAGCCTTTCCTGTTAA