Detailed information of TA system TA226292

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2775779..2776431
• Replicon: chromosome
• Accession: NZ_CP087825
• Organism: Moraxella bovis strain SAM102601

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LP108_RS14085
• Protein ID: WP_078275188.1
• Coordinates: 2776039..2776431 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LP108_RS14080
• Protein ID: WP_264675982.1
• Coordinates: 2775779..2776042 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP108_RS14050 (LP108_13910)	2771064..2772398	+	1335	WP_112741795.1	deoxyguanosinetriphosphate triphosphohydrolase	-
LP108_RS14055 (LP108_13915)	2772542..2772835	+	294	WP_029103533.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
LP108_RS14060 (LP108_13920)	2772828..2773100	+	273	WP_228157760.1	type II toxin-antitoxin system YafQ family toxin	-
LP108_RS14065 (LP108_13925)	2773165..2773620	-	456	WP_264675985.1	type IV secretion protein Rhs	-
LP108_RS14070 (LP108_13930)	2773705..2774082	+	378	WP_264675984.1	hypothetical protein	-
LP108_RS14075 (LP108_13935)	2774440..2775699	+	1260	WP_264675983.1	replication-associated recombination protein A	-
LP108_RS14080 (LP108_13940)	2775779..2776042	+	264	WP_264675982.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
LP108_RS14085 (LP108_13945)	2776039..2776431	+	393	WP_078275188.1	type II toxin-antitoxin system VapC family toxin	Toxin
LP108_RS14090 (LP108_13950)	2776554..2777084	+	531	WP_078275187.1	HI_0552 family protein	-
LP108_RS14095 (LP108_13955)	2777081..2777647	-	567	WP_078275186.1	hypothetical protein	-
LP108_RS14100 (LP108_13960)	2777650..2777886	-	237	WP_078275185.1	sulfurtransferase TusA	-
LP108_RS14105 (LP108_13965)	2777883..2778341	-	459	WP_078275184.1	acyl-CoA thioesterase	-
LP108_RS14110 (LP108_13970)	2778421..2779443	-	1023	WP_078275183.1	hypothetical protein	-
LP108_RS14115 (LP108_13975)	2779474..2780352	-	879	WP_112741796.1	uroporphyrinogen-III synthase	-
LP108_RS14120 (LP108_13980)	2780398..2781339	-	942	WP_078275181.1	hydroxymethylbilane synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-122)

Antitoxin

• SpoVT-AbrB domain (10-50)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14689.79 Da
• Isoelectric Point: 4.7370

>T226292 WP_078275188.1 NZ_CP087825:2776039-2776431 [Moraxella bovis]
MKYLLDTNAVIAILNASERFLTTLERHKEREIAISSIVLSELYYGAYKSQKTAQNLEKINLLPFEVLQFNSQDADKAGEI
GATLERRGTPIGFYDTLIAGQAIANDLIVITDNVREFLRVDGLQIENWLK

Nucleotide

• Length: 393 bp

>T226292 NZ_CP122391:c88599-88183 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCTGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10153.49 Da
• Isoelectric Point: 6.3724

>AT226292 WP_264675982.1 NZ_CP087825:2775779-2776042 [Moraxella bovis]
MRQTATAKLFWTGNSQAVRLPKAFRFEGTEVRIKKQGRQVIIEPAETQDWAWLDKLRAMPKDDSFEEAILEGRQNLKADE
RDWGAFE

Nucleotide

• Length: 264 bp

>AT226292 NZ_CP122391:c88826-88596 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAAGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA