Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1777153..1777811 | Replicon | chromosome |
| Accession | NZ_CP087825 | ||
| Organism | Moraxella bovis strain SAM102601 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | LP108_RS09015 | Protein ID | WP_078274940.1 |
| Coordinates | 1777623..1777811 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | LP108_RS09010 | Protein ID | WP_112741846.1 |
| Coordinates | 1777153..1777560 (-) | Length | 136 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LP108_RS08980 (LP108_08885) | 1772384..1774213 | - | 1830 | WP_078274936.1 | hypothetical protein | - |
| LP108_RS08985 (LP108_08890) | 1774201..1774545 | - | 345 | WP_078274937.1 | hypothetical protein | - |
| LP108_RS08990 (LP108_08895) | 1774546..1775352 | - | 807 | WP_112741850.1 | hypothetical protein | - |
| LP108_RS08995 (LP108_08900) | 1775406..1775843 | - | 438 | WP_162860346.1 | hypothetical protein | - |
| LP108_RS09000 (LP108_08905) | 1775777..1776109 | - | 333 | WP_112741848.1 | hypothetical protein | - |
| LP108_RS09005 (LP108_08910) | 1776106..1777077 | - | 972 | WP_112741847.1 | phage tail tape measure protein | - |
| LP108_RS09010 (LP108_08915) | 1777153..1777560 | - | 408 | WP_112741846.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| LP108_RS09015 (LP108_08920) | 1777623..1777811 | - | 189 | WP_078274940.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| LP108_RS09020 (LP108_08925) | 1777954..1778169 | - | 216 | WP_078274941.1 | hypothetical protein | - |
| LP108_RS09025 (LP108_08930) | 1778171..1778770 | - | 600 | WP_078274942.1 | antA/AntB antirepressor family protein | - |
| LP108_RS09030 (LP108_08935) | 1778877..1779083 | - | 207 | WP_264676102.1 | DNA-binding protein | - |
| LP108_RS09035 (LP108_08940) | 1779206..1779550 | + | 345 | WP_078274944.1 | helix-turn-helix transcriptional regulator | - |
| LP108_RS09040 (LP108_08945) | 1779594..1780346 | - | 753 | WP_078274945.1 | hypothetical protein | - |
| LP108_RS09045 (LP108_08950) | 1780424..1780624 | - | 201 | WP_264676324.1 | hypothetical protein | - |
| LP108_RS09050 (LP108_08955) | 1780633..1780824 | - | 192 | WP_264676101.1 | DNA-binding protein | - |
| LP108_RS09055 (LP108_08960) | 1780839..1781048 | - | 210 | WP_078274960.1 | hypothetical protein | - |
| LP108_RS09060 (LP108_08965) | 1781213..1781512 | + | 300 | WP_078274961.1 | helix-turn-helix transcriptional regulator | - |
| LP108_RS09065 (LP108_08970) | 1781707..1781994 | + | 288 | WP_078274962.1 | ORF6C domain-containing protein | - |
| LP108_RS09070 (LP108_08975) | 1781991..1782410 | + | 420 | WP_112741841.1 | S24 family peptidase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1767135..1782410 | 15275 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7047.13 Da Isoelectric Point: 10.3659
>T226289 WP_078274940.1 NZ_CP087825:c1777811-1777623 [Moraxella bovis]
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD
Download Length: 189 bp
>T226289 NZ_CP122389:c5315597-5315214 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTACCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTACCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
Antitoxin
Download Length: 136 a.a. Molecular weight: 14756.85 Da Isoelectric Point: 4.2244
>AT226289 WP_112741846.1 NZ_CP087825:c1777560-1777153 [Moraxella bovis]
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG
Download Length: 408 bp
>AT226289 NZ_CP122389:c5315839-5315597 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|