Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 966548..967205 Replicon chromosome
Accession NZ_CP087825
Organism Moraxella bovis strain SAM102601

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP108_RS04670 Protein ID WP_264676287.1
Coordinates 966548..966730 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP108_RS04675 Protein ID WP_264676286.1
Coordinates 966792..967205 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP108_RS04645 (LP108_04575) 962521..963918 - 1398 WP_264683497.1 phage terminase large subunit -
LP108_RS04650 (LP108_04580) 963918..964457 - 540 WP_264676291.1 terminase small subunit -
LP108_RS04655 (LP108_04585) 964571..964780 + 210 WP_264676290.1 hypothetical protein -
LP108_RS04660 (LP108_04590) 964817..965017 + 201 WP_264676289.1 helix-turn-helix domain-containing protein -
LP108_RS04665 (LP108_04595) 965444..966148 - 705 WP_264676288.1 BRO family protein -
LP108_RS04670 (LP108_04600) 966548..966730 + 183 WP_264676287.1 type II toxin-antitoxin system HicA family toxin Toxin
LP108_RS04675 (LP108_04605) 966792..967205 + 414 WP_264676286.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP108_RS04680 (LP108_04610) 967216..967617 - 402 WP_264676285.1 antiterminator Q family protein -
LP108_RS04685 (LP108_04615) 967601..967822 - 222 WP_264676284.1 DUF3310 domain-containing protein -
LP108_RS04690 (LP108_04620) 967819..967974 - 156 WP_264683498.1 hypothetical protein -
LP108_RS04695 (LP108_04625) 968111..968596 - 486 WP_078273444.1 recombination protein NinB -
LP108_RS04700 (LP108_04630) 968660..969337 - 678 WP_264682991.1 Bro-N domain-containing protein -
LP108_RS04705 (LP108_04635) 969999..970196 + 198 WP_264682993.1 ribbon-helix-helix domain-containing protein -
LP108_RS04710 (LP108_04640) 970243..970521 - 279 WP_264683499.1 hypothetical protein -
LP108_RS04715 (LP108_04645) 970518..970925 - 408 WP_112742083.1 VRR-NUC domain-containing protein -
LP108_RS04720 (LP108_04650) 970922..971530 - 609 WP_078273440.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 946485..987715 41230


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-79)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6761.81 Da        Isoelectric Point: 10.7622

>T226283 WP_264676287.1 NZ_CP087825:966548-966730 [Moraxella bovis]
MKYSEFQRWLLAQGATVNKQGGKGSHRKVTLNGKTTTFPYHGSKEIGEGLRKKILKDLDL

Download         Length: 183 bp

>T226283 NZ_CP122389:c3958699-3958382 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACTCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15339.53 Da        Isoelectric Point: 4.7523

>AT226283 WP_264676286.1 NZ_CP087825:966792-967205 [Moraxella bovis]
MYYPATFTPDTNDTFLVAFRDIPEAVGVGETFEIAYQSALDGLETAFSIYMDERKPIPAPSELSDGEHAIYLPVAVQTKL
ALYHEMLAQGVTKAELARRLSVNQKQIDRLWDVSHSTKLEFLEKAFSVLGKRLSLAI

Download         Length: 414 bp

>AT226283 NZ_CP122389:c3958389-3958102 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References