Detailed information of TA system TA226280

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 2409146..2409704
• Replicon: chromosome
• Accession: NZ_CP087823
• Organism: Moraxella bovis strain SAM102602

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LP123_RS12275
• Protein ID: WP_228157760.1
• Coordinates: 2409146..2409418 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1S9ZVK6
• Locus tag: LP123_RS12280
• Protein ID: WP_029103533.1
• Coordinates: 2409411..2409704 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP123_RS12235 (LP123_12120)	2404392..2404628	+	237	WP_078275185.1	sulfurtransferase TusA	-
LP123_RS12240 (LP123_12125)	2404631..2405197	+	567	WP_078275186.1	hypothetical protein	-
LP123_RS12245 (LP123_12130)	2405194..2405724	-	531	WP_078275187.1	HI_0552 family protein	-
LP123_RS12250 (LP123_12135)	2405847..2406239	-	393	WP_078275188.1	type II toxin-antitoxin system VapC family toxin	-
LP123_RS12255 (LP123_12140)	2406236..2406499	-	264	WP_078275189.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
LP123_RS12260 (LP123_12145)	2406579..2407838	-	1260	WP_078275190.1	replication-associated recombination protein A	-
LP123_RS12265 (LP123_12150)	2407817..2408590	-	774	WP_078275191.1	hypothetical protein	-
LP123_RS12270 (LP123_12155)	2408641..2409081	+	441	WP_208624064.1	type IV secretion protein Rhs	-
LP123_RS12275 (LP123_12160)	2409146..2409418	-	273	WP_228157760.1	type II toxin-antitoxin system YafQ family toxin	Toxin
LP123_RS12280 (LP123_12165)	2409411..2409704	-	294	WP_029103533.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LP123_RS12285 (LP123_12170)	2409848..2411182	-	1335	WP_112741795.1	deoxyguanosinetriphosphate triphosphohydrolase	-
LP123_RS12290 (LP123_12175)	2411391..2412107	-	717	WP_078275193.1	hypothetical protein	-
LP123_RS12295 (LP123_12180)	2412128..2412739	-	612	WP_112741794.1	methyltransferase	-
LP123_RS12300 (LP123_12185)	2412859..2414193	+	1335	WP_078275195.1	valine--pyruvate transaminase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2388089..2419349	31260

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (6-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-67)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10415.99 Da
• Isoelectric Point: 6.9668

>T226280 WP_228157760.1 NZ_CP087823:c2409418-2409146 [Moraxella bovis]
VAKRSFEMGNPFKRDLKKHYLALIGEAWTEVSDCLLNAKPIPQKYQDHPLQGDWVGFRDCHIKPDLVLIYKINDEAVELH
RLATHSELFG

Nucleotide

• Length: 273 bp

>T226280 NZ_CP087823:c2409418-2409146 [Moraxella bovis]
GTGGCTAAACGTAGTTTTGAAATGGGCAATCCCTTTAAAAGGGATTTAAAAAAGCATTATTTGGCATTGATTGGCGAAGC
GTGGACGGAAGTGTCTGATTGCTTGTTAAATGCCAAACCCATACCTCAAAAATACCAAGACCACCCATTGCAAGGCGATT
GGGTGGGGTTTAGAGATTGTCATATCAAGCCTGATTTGGTGCTAATTTATAAAATAAATGATGAAGCGGTGGAATTACAT
CGGCTTGCCACGCATAGCGAGTTGTTTGGTTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11068.31 Da
• Isoelectric Point: 4.7769

>AT226280 WP_029103533.1 NZ_CP087823:c2409704-2409411 [Moraxella bovis]
MSHTNFNMRLDNDLRQKAYPVLEQYGLTPSQAVRMFFNQIAQTGKVPLSFDWGQSHTLSSNGEKLLRESIQAFENGETER
FDSLDELNQAMAEIARG

Nucleotide

• Length: 294 bp

>AT226280 NZ_CP087823:c2409704-2409411 [Moraxella bovis]
ATGAGCCACACCAATTTTAATATGCGATTAGACAACGACCTACGCCAAAAAGCCTATCCTGTGCTAGAACAATACGGCTT
GACTCCAAGCCAAGCAGTGCGGATGTTTTTTAATCAAATCGCCCAAACAGGCAAAGTGCCATTGTCTTTTGATTGGGGGC
AGTCGCATACGCTTAGTAGCAATGGCGAAAAGCTGTTGCGTGAGAGTATTCAAGCTTTTGAAAATGGCGAAACCGAGCGA
TTTGATAGCTTAGATGAGTTAAATCAAGCAATGGCGGAGATTGCTCGTGGCTAA

Structures

Antitoxin

• AlphaFold DB: A0A1S9ZVK6