Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2405847..2406499 Replicon chromosome
Accession NZ_CP087823
Organism Moraxella bovis strain SAM102602

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP123_RS12250 Protein ID WP_078275188.1
Coordinates 2405847..2406239 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP123_RS12255 Protein ID WP_078275189.1
Coordinates 2406236..2406499 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP123_RS12215 (LP123_12100) 2400939..2401880 + 942 WP_078275181.1 hydroxymethylbilane synthase -
LP123_RS12220 (LP123_12105) 2401926..2402804 + 879 WP_112741796.1 uroporphyrinogen-III synthase -
LP123_RS12225 (LP123_12110) 2402835..2403857 + 1023 WP_078275183.1 hypothetical protein -
LP123_RS12230 (LP123_12115) 2403937..2404395 + 459 WP_078275184.1 acyl-CoA thioesterase -
LP123_RS12235 (LP123_12120) 2404392..2404628 + 237 WP_078275185.1 sulfurtransferase TusA -
LP123_RS12240 (LP123_12125) 2404631..2405197 + 567 WP_078275186.1 hypothetical protein -
LP123_RS12245 (LP123_12130) 2405194..2405724 - 531 WP_078275187.1 HI_0552 family protein -
LP123_RS12250 (LP123_12135) 2405847..2406239 - 393 WP_078275188.1 type II toxin-antitoxin system VapC family toxin Toxin
LP123_RS12255 (LP123_12140) 2406236..2406499 - 264 WP_078275189.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LP123_RS12260 (LP123_12145) 2406579..2407838 - 1260 WP_078275190.1 replication-associated recombination protein A -
LP123_RS12265 (LP123_12150) 2407817..2408590 - 774 WP_078275191.1 hypothetical protein -
LP123_RS12270 (LP123_12155) 2408641..2409081 + 441 WP_208624064.1 type IV secretion protein Rhs -
LP123_RS12275 (LP123_12160) 2409146..2409418 - 273 WP_228157760.1 type II toxin-antitoxin system YafQ family toxin -
LP123_RS12280 (LP123_12165) 2409411..2409704 - 294 WP_029103533.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
LP123_RS12285 (LP123_12170) 2409848..2411182 - 1335 WP_112741795.1 deoxyguanosinetriphosphate triphosphohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2388089..2419349 31260


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-122)

Antitoxin

SpoVT-AbrB domain

(10-50)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14689.79 Da        Isoelectric Point: 4.7370

>T226279 WP_078275188.1 NZ_CP087823:c2406239-2405847 [Moraxella bovis]
MKYLLDTNAVIAILNASERFLTTLERHKEREIAISSIVLSELYYGAYKSQKTAQNLEKINLLPFEVLQFNSQDADKAGEI
GATLERRGTPIGFYDTLIAGQAIANDLIVITDNVREFLRVDGLQIENWLK

Download         Length: 393 bp

>T226279 NZ_CP122389:795159-795644 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10183.52 Da        Isoelectric Point: 6.3724

>AT226279 WP_078275189.1 NZ_CP087823:c2406499-2406236 [Moraxella bovis]
MRQTATAKLFWTGNSQAVRLPKTFRFEGTEVRIKKQGRQVIIEPAETQDWAWLDKLRAMPKDDSFEEAILEGRQNLKADE
RDWGAFE

Download         Length: 264 bp

>AT226279 NZ_CP122389:794869-795162 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References