Detailed information of TA system TA226278

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 1267140..1267629
• Replicon: chromosome
• Accession: NZ_CP087823
• Organism: Moraxella bovis strain SAM102602

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LP123_RS06760
• Protein ID: WP_264676856.1
• Coordinates: 1267372..1267629 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: LP123_RS06755
• Protein ID: WP_228157840.1
• Coordinates: 1267140..1267382 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP123_RS06715 (LP123_06665)	1262230..1263279	+	1050	WP_264689785.1	RluA family pseudouridine synthase	-
LP123_RS06720 (LP123_06670)	1263398..1264195	+	798	WP_264676861.1	polyphenol oxidase family protein	-
LP123_RS06725	1264192..1264404	+	213	WP_264676860.1	bestrophin family protein	-
LP123_RS06730 (LP123_06675)	1264394..1264801	+	408	WP_264676859.1	bestrophin family protein	-
LP123_RS06735	1265082..1265605	+	524	Protein_1316	DUF853 family protein	-
LP123_RS06740 (LP123_06680)	1265592..1266539	+	948	WP_264676857.1	DUF853 domain-containing protein	-
LP123_RS06745 (LP123_06685)	1266562..1266849	+	288	WP_115005096.1	DUF1315 family protein	-
LP123_RS06750 (LP123_06690)	1266931..1267095	-	165	WP_158079593.1	hypothetical protein	-
LP123_RS06755 (LP123_06695)	1267140..1267382	+	243	WP_228157840.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
LP123_RS06760 (LP123_06700)	1267372..1267629	+	258	WP_264676856.1	Txe/YoeB family addiction module toxin	Toxin
LP123_RS06765 (LP123_06705)	1267688..1268197	+	510	WP_264676855.1	peptidylprolyl isomerase	-
LP123_RS06770 (LP123_06710)	1268264..1269067	+	804	WP_264676854.1	UDP-2,3-diacylglucosamine diphosphatase	-
LP123_RS06775 (LP123_06715)	1269164..1271650	-	2487	WP_264684011.1	alpha/beta hydrolase	-
LP123_RS06780 (LP123_06720)	1271753..1272601	-	849	WP_264676852.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-68)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10488.00 Da
• Isoelectric Point: 8.1158

>T226278 WP_264676856.1 NZ_CP087823:1267372-1267629 [Moraxella bovis]
MRIRWFDEVWEDYLYWQSQDKKTIKRINTLIKDCRRDPFDGIGKPEPLKYNLTGYWLRRINDANRLVYCCESETLIISCR
HHYEA

Nucleotide

• Length: 258 bp

>T226278 NZ_CP122389:350363-350710 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGACGATTACTATGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9134.23 Da
• Isoelectric Point: 6.2120

>AT226278 WP_228157840.1 NZ_CP087823:1267140-1267382 [Moraxella bovis]
MNYSEFRQNLASALDYVQDSHAPVIVKRGKHSAVVISLDEYNAFKETDYLLSNPANAEHLMRGVQAVKNRQLTQRDLIED

Nucleotide

• Length: 243 bp

>AT226278 NZ_CP122389:350710-351009 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA