Detailed information of TA system TA226277

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): AbkB-shpB/BrnT-BrnA
• Location: 1056222..1056774
• Replicon: chromosome
• Accession: NZ_CP087823
• Organism: Moraxella bovis strain SAM102602

Toxin (Protein)

• Gene name: AbkB
• Uniprot ID: A0A1T0A7D3
• Locus tag: LP123_RS05535
• Protein ID: WP_029102268.1
• Coordinates: 1056496..1056774 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: -
• Locus tag: LP123_RS05530
• Protein ID: WP_078273473.1
• Coordinates: 1056222..1056509 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP123_RS05510 (LP123_05480)	1051657..1052706	+	1050	WP_264683526.1	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	-
LP123_RS05515 (LP123_05485)	1052785..1054284	+	1500	WP_112742120.1	DUF389 domain-containing protein	-
LP123_RS05520	1054313..1054438	+	126	WP_264676709.1	hypothetical protein	-
LP123_RS05525 (LP123_05490)	1054482..1056212	-	1731	WP_078273474.1	flotillin domain-containing protein	-
LP123_RS05530 (LP123_05495)	1056222..1056509	-	288	WP_078273473.1	BrnA antitoxin family protein	Antitoxin
LP123_RS05535 (LP123_05500)	1056496..1056774	-	279	WP_029102268.1	BrnT family toxin	Toxin
LP123_RS05540 (LP123_05505)	1056869..1057525	-	657	WP_078273472.1	YqiJ family protein	-
LP123_RS05545 (LP123_05510)	1057725..1058390	-	666	WP_078273471.1	PspA/IM30 family protein	-
LP123_RS05550 (LP123_05515)	1058603..1058785	-	183	WP_264683628.1	hypothetical protein	-
LP123_RS05555 (LP123_05520)	1058886..1059401	-	516	WP_078273469.1	hypothetical protein	-
LP123_RS05560 (LP123_05525)	1059549..1059899	-	351	WP_078273468.1	TIGR01244 family sulfur transferase	-
LP123_RS05565 (LP123_05530)	1060011..1060787	+	777	WP_078273467.1	nucleotidyltransferase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-85)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (36-89)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10484.81 Da
• Isoelectric Point: 5.1084

>T226277 WP_029102268.1 NZ_CP087823:c1056774-1056496 [Moraxella bovis]
MIFEWDDNKNRTNKQKHGVSFESASRIFLDPFLIVTEDTSSDEVRWLGVGSVDGVVILLVVHTHTDTDGTEIIRIISARK
LSRGEIERYGYC

Nucleotide

• Length: 279 bp

>T226277 NZ_CP122389:324392-324760 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10979.71 Da
• Isoelectric Point: 7.0097

>AT226277 WP_078273473.1 NZ_CP087823:c1056509-1056222 [Moraxella bovis]
MAIVRKTLDDIKHTPIDKDELAQLQSMSDDSINYDDIPPLTDVQIANLRLYKPIKQQITLRLDSDIVAWLKKDGKGYQTR
ANQLLRQLMLKELTT

Nucleotide

• Length: 288 bp

>AT226277 NZ_CP122389:324174-324395 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: A0A1T0A7D3