Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 729130..729779 Replicon chromosome
Accession NZ_CP087823
Organism Moraxella bovis strain SAM102602

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP123_RS03705 Protein ID WP_078274052.1
Coordinates 729378..729779 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP123_RS03700 Protein ID WP_112741908.1
Coordinates 729130..729363 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP123_RS03680 (LP123_03660) 724526..724975 - 450 WP_264676133.1 cytochrome c -
LP123_RS03685 (LP123_03665) 725157..726149 - 993 WP_078274055.1 oxygen-dependent coproporphyrinogen oxidase -
LP123_RS03690 (LP123_03670) 726169..726762 - 594 WP_208624078.1 GTP cyclohydrolase II -
LP123_RS03695 (LP123_03675) 726983..729082 + 2100 WP_078274054.1 1-deoxy-D-xylulose-5-phosphate synthase -
LP123_RS03700 (LP123_03680) 729130..729363 + 234 WP_112741908.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP123_RS03705 (LP123_03685) 729378..729779 + 402 WP_078274052.1 type II toxin-antitoxin system VapC family toxin Toxin
LP123_RS03710 (LP123_03690) 730303..730803 + 501 WP_112741909.1 WG repeat-containing protein -
LP123_RS03715 (LP123_03695) 730925..731755 + 831 WP_078274050.1 inositol monophosphatase family protein -
LP123_RS03720 (LP123_03700) 731854..732543 - 690 WP_078274049.1 SIMPL domain-containing protein -
LP123_RS03730 (LP123_03710) 733279..733698 - 420 WP_078274047.1 S4 domain-containing protein -
LP123_RS03735 (LP123_03715) 733695..733871 - 177 WP_228157829.1 ASCH domain-containing protein -
LP123_RS03740 (LP123_03720) 733890..734123 - 234 WP_112741910.1 ASCH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15131.33 Da        Isoelectric Point: 6.8510

>T226274 WP_078274052.1 NZ_CP087823:729378-729779 [Moraxella bovis]
MFSFMLDTNIYIYVIKERPIKALNKFNQYAGRICVSSIVASELYFGAYNSQFMDKNLHQVEDFLSRLTVLDYTAECSPHY
GEICADLTKQGKLISENDIHIASHARALGLTLITNNTDEFKRVSGLRIGNWAI

Download         Length: 402 bp

>T226274 NZ_CP122379:c2318623-2318369 [Aequorivita sp. Ant34-E75]
ATGCAAATTACAACCGTTTCGGACTTTAGAAAGGATATTAAAACGTACTTAGATCGAGTTGTAAAGAACGTTGAAACTTT
AATTATTAATCGCGGAAAGGATTCTGGAATAGTAATCATGTCTTTGCAGGAGTACAATTCCTTAATGGCTACAAATCACG
AATTGTCTTCTCGAAAGAATGAAAGGAGATTAGATTCTGCAATTGACAAACTTAATAGCGGATCTACTTTTAACAAAGAA
CTAATCGAAGATTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8990.22 Da        Isoelectric Point: 6.2884

>AT226274 WP_112741908.1 NZ_CP087823:729130-729363 [Moraxella bovis]
MQTSVFFNNRTQAVRIPAKFRFDDDVKAVMIRKVGNERILTPIDGVWDSFFLSDERASDDFMANRPTMPKSERLTFD

Download         Length: 234 bp

>AT226274 NZ_CP122379:c2318367-2318110 [Aequorivita sp. Ant34-E75]
ATGAAGTATATTTTTGTCGACGAATCTTGGGAAGATTATCTGTATTGGCAAAAAACCGACAAAAAGAAGTTGAAAAAAAT
AAATGAAATTCTAAAAGATATCGCTCGAAATCCTTTTGATGGCATTGGAAAACCTGAACCTTTAAAACACAAATACGCTG
GCTTCTGGTCTAGGCGAATTGATAGCGAACATAGGCTAATTTATAAATTTAAAGAGGGTGAAATATTAATTGCAAAATGC
CGCTTCCATTACGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References