Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 568734..569392 Replicon chromosome
Accession NZ_CP087823
Organism Moraxella bovis strain SAM102602

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP123_RS02895 Protein ID WP_078274940.1
Coordinates 568734..568922 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP123_RS02900 Protein ID WP_112741846.1
Coordinates 568985..569392 (+) Length 136 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP123_RS02840 (LP123_02825) 564135..564554 - 420 WP_112741841.1 S24 family peptidase -
LP123_RS02845 (LP123_02830) 564551..564838 - 288 WP_078274962.1 ORF6C domain-containing protein -
LP123_RS02850 (LP123_02835) 565033..565332 - 300 WP_078274961.1 helix-turn-helix transcriptional regulator -
LP123_RS02855 (LP123_02840) 565497..565706 + 210 WP_078274960.1 hypothetical protein -
LP123_RS02860 (LP123_02845) 565721..565912 + 192 WP_264676101.1 DNA-binding protein -
LP123_RS02865 (LP123_02850) 565921..566121 + 201 WP_264676324.1 hypothetical protein -
LP123_RS02870 (LP123_02855) 566199..566951 + 753 WP_078274945.1 hypothetical protein -
LP123_RS02875 (LP123_02860) 566995..567339 - 345 WP_078274944.1 helix-turn-helix transcriptional regulator -
LP123_RS02880 (LP123_02865) 567462..567668 + 207 WP_264676102.1 DNA-binding protein -
LP123_RS02885 (LP123_02870) 567775..568374 + 600 WP_078274942.1 antA/AntB antirepressor family protein -
LP123_RS02890 (LP123_02875) 568376..568591 + 216 WP_078274941.1 hypothetical protein -
LP123_RS02895 (LP123_02880) 568734..568922 + 189 WP_078274940.1 type II toxin-antitoxin system HicA family toxin Toxin
LP123_RS02900 (LP123_02885) 568985..569392 + 408 WP_112741846.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP123_RS02905 (LP123_02890) 569468..570439 + 972 WP_112741847.1 phage tail tape measure protein -
LP123_RS02910 (LP123_02895) 570436..570768 + 333 WP_112741848.1 hypothetical protein -
LP123_RS02915 (LP123_02900) 570702..571139 + 438 WP_162860346.1 hypothetical protein -
LP123_RS02920 (LP123_02905) 571193..571999 + 807 WP_264684230.1 hypothetical protein -
LP123_RS02925 (LP123_02910) 572000..572344 + 345 WP_078274937.1 hypothetical protein -
LP123_RS02930 (LP123_02915) 572332..574161 + 1830 WP_078274936.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 550807..578629 27822


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 63 a.a.        Molecular weight: 7047.13 Da        Isoelectric Point: 10.3659

>T226273 WP_078274940.1 NZ_CP087823:568734-568922 [Moraxella bovis]
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD

Download         Length: 189 bp

>T226273 NZ_CP122379:c2318367-2318110 [Aequorivita sp. Ant34-E75]
ATGAAGTATATTTTTGTCGACGAATCTTGGGAAGATTATCTGTATTGGCAAAAAACCGACAAAAAGAAGTTGAAAAAAAT
AAATGAAATTCTAAAAGATATCGCTCGAAATCCTTTTGATGGCATTGGAAAACCTGAACCTTTAAAACACAAATACGCTG
GCTTCTGGTCTAGGCGAATTGATAGCGAACATAGGCTAATTTATAAATTTAAAGAGGGTGAAATATTAATTGCAAAATGC
CGCTTCCATTACGACTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14756.85 Da        Isoelectric Point: 4.2244

>AT226273 WP_112741846.1 NZ_CP087823:568985-569392 [Moraxella bovis]
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG

Download         Length: 408 bp

>AT226273 NZ_CP122379:c2318623-2318369 [Aequorivita sp. Ant34-E75]
ATGCAAATTACAACCGTTTCGGACTTTAGAAAGGATATTAAAACGTACTTAGATCGAGTTGTAAAGAACGTTGAAACTTT
AATTATTAATCGCGGAAAGGATTCTGGAATAGTAATCATGTCTTTGCAGGAGTACAATTCCTTAATGGCTACAAATCACG
AATTGTCTTCTCGAAAGAATGAAAGGAGATTAGATTCTGCAATTGACAAACTTAATAGCGGATCTACTTTTAACAAAGAA
CTAATCGAAGATTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References