Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2392158..2392782 Replicon chromosome
Accession NZ_CP087821
Organism Moraxella bovis strain SAM102604

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP102_RS11780 Protein ID WP_264677651.1
Coordinates 2392480..2392782 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP102_RS11775 Protein ID WP_264677652.1
Coordinates 2392158..2392493 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP102_RS11750 (LP102_11655) 2387270..2388340 + 1071 WP_115368772.1 5'-nucleotidase -
LP102_RS11755 (LP102_11660) 2388549..2388866 + 318 WP_078274423.1 H-NS histone family protein -
LP102_RS11760 (LP102_11665) 2389326..2390066 + 741 WP_112742704.1 single-stranded DNA-binding protein -
LP102_RS11765 (LP102_11670) 2390241..2391473 + 1233 WP_264677654.1 beta-ketoacyl-ACP synthase II -
LP102_RS11770 (LP102_11675) 2391661..2392125 + 465 WP_264677653.1 hypothetical protein -
LP102_RS11775 (LP102_11680) 2392158..2392493 - 336 WP_264677652.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP102_RS11780 (LP102_11685) 2392480..2392782 - 303 WP_264677651.1 type II toxin-antitoxin system HicA family toxin Toxin
LP102_RS11785 (LP102_11690) 2392920..2394275 + 1356 WP_264677650.1 anthranilate synthase component I family protein -
LP102_RS11790 (LP102_11695) 2394385..2395503 + 1119 WP_264677649.1 acyl-CoA dehydrogenase family protein -
LP102_RS11800 (LP102_11705) 2395522..2396877 + 1356 WP_272506296.1 FAD-dependent oxidoreductase -
LP102_RS11805 (LP102_11710) 2397134..2397688 - 555 WP_078274416.1 porin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(21-73)

Antitoxin

Uncharacterised protein family HicB

(52-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11427.89 Da        Isoelectric Point: 6.3267

>T226272 WP_264677651.1 NZ_CP087821:c2392782-2392480 [Moraxella bovis]
MTKSDKLKAKLYGDVRTFVFSDLVTLLSQLGYEMHERAGSRVVFVHCDDNSDRIHLHKPHPENTIKGGALKAVKAYLSEK
GYFDEFNDDVLNQELKNDDL

Download         Length: 303 bp

>T226272 NZ_CP122328:3880065-3880418 [Pantoea agglomerans pv. betae]
ATGTGGACCGTACTCCTGAGCCCGCGCTTTGAAAGCTGGCTAAGTGAGCAGGAAGAAGCCCTGCAGGAAAAAATGTTAGC
GGATCCGGGAAAGTTAAAAGTATACGGCCCTGATTTGCCTCGCCCTTATGCTGATACTCTCAAGGGTTCGCAGTACAGGA
ATATGAAAGAACTCTGCGTACAGTTTTCAGGAAAGCCATTTCGGGCATTTTATGCATTTGACCCTGTCCGCCAGGCTATT
GTGTTATGTGCCGGAGATAAGAGTCATGACAAACGTTTTTATATCCGAATGATACGCATCGCTGACGATGAATTTTCAGC
CTGGCTGGCTGAACAGGAGAAGGGAAATAATTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12590.10 Da        Isoelectric Point: 4.4118

>AT226272 WP_264677652.1 NZ_CP087821:c2392493-2392158 [Moraxella bovis]
MMTYKGYVGEFTLDNDDEIFYGKLIGINQLVTFEADNAHDLKQAFYDSVDDYLAFCAEQGIEPDKPFKGSFNVRIDSELH
RRAYMASRDSSLNAFVGQAISEKLNRMAVSI

Download         Length: 336 bp

>AT226272 NZ_CP122328:3880418-3880717 [Pantoea agglomerans pv. betae]
ATGAGAACCCTGGATGATGTTATCGCCGACTTCTCCCCTGAGAGTCAGGCGCGAATCAAAAAAATGTCTGATGAAATGAT
TCTGGAAGTCGGGCTTCAGATGATTCGCGAAGAGCTTCAGTTATCACAAAAGACGCTCGCCGAGGCCATGGGCGTGCGTC
AGCCTGCCGTTGCTCAGATTGAGCAACGCGGAAATGAGATTAAGGTTGCCACGCTGAAACGCTATGTCGAAGCAATGGGC
GGAAAACTCAGTCTTGATGTGGAACTTCCGACCGGAAAAAGAGTGGCCTTTCGCATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References