Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1951058..1951707 Replicon chromosome
Accession NZ_CP087821
Organism Moraxella bovis strain SAM102604

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP102_RS09480 Protein ID WP_264677937.1
Coordinates 1951058..1951459 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP102_RS09485 Protein ID WP_112741908.1
Coordinates 1951474..1951707 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP102_RS09450 (LP102_09370) 1946711..1946884 + 174 WP_264677941.1 hypothetical protein -
LP102_RS09455 (LP102_09375) 1947136..1947555 + 420 WP_264677940.1 S4 domain-containing protein -
LP102_RS09465 (LP102_09385) 1948293..1948982 + 690 WP_264677939.1 SIMPL domain-containing protein -
LP102_RS09470 (LP102_09390) 1949082..1949912 - 831 WP_264677938.1 inositol monophosphatase family protein -
LP102_RS09475 (LP102_09395) 1950034..1950534 - 501 WP_112741909.1 WG repeat-containing protein -
LP102_RS09480 (LP102_09400) 1951058..1951459 - 402 WP_264677937.1 type II toxin-antitoxin system VapC family toxin Toxin
LP102_RS09485 (LP102_09405) 1951474..1951707 - 234 WP_112741908.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP102_RS09490 (LP102_09410) 1951755..1953854 - 2100 WP_264683682.1 1-deoxy-D-xylulose-5-phosphate synthase -
LP102_RS09495 (LP102_09415) 1954075..1954668 + 594 WP_208624078.1 GTP cyclohydrolase II -
LP102_RS09500 (LP102_09420) 1954688..1955680 + 993 WP_264683684.1 oxygen-dependent coproporphyrinogen oxidase -
LP102_RS09505 (LP102_09425) 1955862..1956311 + 450 WP_264683685.1 cytochrome c -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15071.29 Da        Isoelectric Point: 6.8426

>T226271 WP_264677937.1 NZ_CP087821:c1951459-1951058 [Moraxella bovis]
MFSFMLDTNICIYVIKERPIKALNKFNQYAGRICVSSIVASELYFGAYNSQFMDKNLHQVEDFLSRLTVLDYTAECSPHY
GEICADLTKQGKLISENDIHIASHARALGLTLITNNTDEFKRVSGLRIGNWAI

Download         Length: 402 bp

>T226271 NZ_CP122328:c3438441-3438262 [Pantoea agglomerans pv. betae]
ATGGATAGCAGCACGTTAATTTCCGAAATGAAGGCTGATGGCTGGGTTCTGACAAGGATAAACGGTAGCCCTCACCATTT
CACACATCCGACAAAACCGGGGCTGGTTACAGTACCCCATCCTAAAAAAGACTTACCGATCGGTACGGTAAAGAGCATCA
GGAAACAAGCGAGAATTTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8990.22 Da        Isoelectric Point: 6.2884

>AT226271 WP_112741908.1 NZ_CP087821:c1951707-1951474 [Moraxella bovis]
MQTSVFFNNRTQAVRIPAKFRFDDDVKAVMIRKVGNERILTPIDGVWDSFFLSDERASDDFMANRPTMPKSERLTFD

Download         Length: 234 bp

>AT226271 NZ_CP122328:c3438235-3437810 [Pantoea agglomerans pv. betae]
ATGTTTTATCCAATCGCGATTGAAGCGGGTGATCATGAAAACGCATACGGCGTAACCGTTCCCGATTTACCAGGGTGTTT
CTCTGCCGGGGATACTCTTGATGAAGCCATTAAAAACGCCAAAGAGGCTATCACAGGGCATATCGAATTATGTGTAGAGC
TCGGTCATGAGATCCCTGCCGTGTCCACCATTGAGGCTCTGGCAGCGAATCCTGACTATCAGGATTATATCTGGGCATTG
GTTGATGTAGATGTCATTCGCTTGCTGGGCGGCTCTGAAAAAATCAATGTCACTTTACCCAGGTCGCTAATTGATCGGAT
TGATCGTTGTGTGGCTTCACACCCGGAATACAAAAGTCGCTCAGGCTTTCTGGCTCAGGTAGCGCTTGAGCGTATTACCG
CTCCGATTAACAGGCCTCAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References