Detailed information of TA system TA226269

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): AbkB-shpB/BrnT-BrnA
• Location: 1651920..1652472
• Replicon: chromosome
• Accession: NZ_CP087821
• Organism: Moraxella bovis strain SAM102604

Toxin (Protein)

• Gene name: AbkB
• Uniprot ID: A0A1T0A7D3
• Locus tag: LP102_RS08030
• Protein ID: WP_029102268.1
• Coordinates: 1651920..1652198 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: -
• Locus tag: LP102_RS08035
• Protein ID: WP_078273473.1
• Coordinates: 1652185..1652472 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP102_RS08000 (LP102_07930)	1647906..1648682	-	777	WP_264678118.1	nucleotidyltransferase domain-containing protein	-
LP102_RS08005 (LP102_07935)	1648795..1649145	+	351	WP_078273468.1	TIGR01244 family sulfur transferase	-
LP102_RS08010 (LP102_07940)	1649293..1649808	+	516	WP_264678117.1	hypothetical protein	-
LP102_RS08015 (LP102_07945)	1649909..1650091	+	183	WP_264683628.1	hypothetical protein	-
LP102_RS08020 (LP102_07950)	1650304..1650969	+	666	WP_264678115.1	PspA/IM30 family protein	-
LP102_RS08025 (LP102_07955)	1651169..1651825	+	657	WP_264678114.1	YqiJ family protein	-
LP102_RS08030 (LP102_07960)	1651920..1652198	+	279	WP_029102268.1	BrnT family toxin	Toxin
LP102_RS08035 (LP102_07965)	1652185..1652472	+	288	WP_078273473.1	BrnA antitoxin family protein	Antitoxin
LP102_RS08040 (LP102_07970)	1652482..1654212	+	1731	WP_078273474.1	flotillin domain-containing protein	-
LP102_RS08045	1654256..1654381	-	126	WP_264676709.1	hypothetical protein	-
LP102_RS08050 (LP102_07975)	1654410..1655930	-	1521	WP_264678113.1	DUF389 domain-containing protein	-
LP102_RS08055 (LP102_07980)	1656009..1657058	-	1050	WP_264678112.1	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-85)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (36-89)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10484.81 Da
• Isoelectric Point: 5.1084

>T226269 WP_029102268.1 NZ_CP087821:1651920-1652198 [Moraxella bovis]
MIFEWDDNKNRTNKQKHGVSFESASRIFLDPFLIVTEDTSSDEVRWLGVGSVDGVVILLVVHTHTDTDGTEIIRIISARK
LSRGEIERYGYC

Nucleotide

• Length: 279 bp

>T226269 NZ_CP122328:2132064-2133377 [Pantoea agglomerans pv. betae]
ATGCAAAGGCTGATTGCGTGGATGAACGGCGAGCGGGTAGGCGTACTCACCCGCCAGCGAAACGGCGCTCATGAGTTTCA
GTATGATACCGCCTGGCTGAGTAATCCGCTCTCCAGGCCGCTGTCACTTTCGATGCCGTTGCAGGTTAAAGCGATCACCT
CACACGCCGTGATTAACTTCTTCGATAACCTGCTGCCGGATAGCCCATTGATCCGCGACAGAATCGTGGCGCGTTACCAG
ATTAAATCCCGTCAGCCGTTTGATCTGTTGCAGGAAGTGGGACGTGACAGCGTCGGGGCAACCATGTTGCTGCCGCCCGA
TATGCCACTGCCCGCACTGCAGGCCCGCTATGAAGTGCTGGATGAAACCCGGCTGGAAAGCGTGCTGTCGGCCTATCAGT
CAGATATCCCGCTGGGGATGCTGCGTGAAGAGACCGATTTCCGCATCTCGGTCGCGGGGGCGCAGGAGAAAACTGCACTG
CTGCTGACCGATGAAGGCTGGAGCATTCCTGCCGGTGCCACGCCCACCTCGCACATCATTAAGCTGCCGATCGGAGAGAT
TAAACAGCCGGCCGCGACGCTGGATATGCGCGAAAGTGTGGAGAATGAGTATCTCTGTCTGGCGCTGGCCCGTGCACTCG
GTATCGACGTGCCGCAGGCAACGATTATCCGTGCCGGACAGATGCGCGCCCTGGCGGTAGAACGTTTCGACCGCCGCTGG
TCACGCGATAAAACCCGGTTGATCCGCCTGCCGCAGGAGGATTTCTGTCAGGCGCTGGGACTGCCATCTTCAACCAAATA
TGAGTCGGATGGCGGGCCGGGCATTGCGGAGATCATGCAGATACTGATGGGATCGAGCAACGCCATCGAAGATCGCTATC
GCTTTATGATGTTCCAGGTGTTTCAGTGGCTGATTGGCGCAACCGACGGTCACGCCAAGAACTTCTCACTGTTTATTGAG
CGCGGCGGCAGTTATCGACTGACTCCCTTTTATGATGTGATCTCCGCTTACCCGGTACTGGGCGGCACCGGTCTGAACAA
GCGAGCGCTGAAACTGGCGATGGGTCTGCGTGCCACTAAGGGGAAGAAGACAGAGATCGACAAAATCTTCCCGCGCCATT
TTATCGCCACGGCAAAAAGCGTCAGTTTTGATCGTGAGAGTTTGCAGCAGATCTTCGACTTCTTTATTAAGGCCTTTCCC
CAGGCGGTAGTCTCGGTGCGCGATGCTTTGCCGCCAGATTTCCCGCAGCACATCGCCGACGCCATCTTCAGTCACTCACT
GATTATGCTGGAGCGGTTGCGGCACAAAGAGTGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10979.71 Da
• Isoelectric Point: 7.0097

>AT226269 WP_078273473.1 NZ_CP087821:1652185-1652472 [Moraxella bovis]
MAIVRKTLDDIKHTPIDKDELAQLQSMSDDSINYDDIPPLTDVQIANLRLYKPIKQQITLRLDSDIVAWLKKDGKGYQTR
ANQLLRQLMLKELTT

Nucleotide

• Length: 288 bp

>AT226269 NZ_CP122328:2131816-2132064 [Pantoea agglomerans pv. betae]
ATGATATACAGCCCGCTACAGCTGGCAAACCGGCTAAAGCTCATTCGTCAGCGCAATGGCTGGACCCAGAGTGAGCTGGC
GAAAAAGGTCGGCCTGAAACAGGCTACCATCTCTCACTTTGAAAATGCCCCTGACAGCACCTCGCTGGCAACGCTGTTTA
AGCTGTTACAGTCGCTGGAGCTGAGTCTGGAAGTTCAGGAGAAAGAGGAGGCCAGTGCGCCTCAGCTGCATGATGAGGAT
GAGTGGTAA

Structures

Toxin

• AlphaFold DB: A0A1T0A7D3