Detailed information of TA system TA226268

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 1163647..1164136
• Replicon: chromosome
• Accession: NZ_CP087821
• Organism: Moraxella bovis strain SAM102604

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LP102_RS05605
• Protein ID: WP_264676856.1
• Coordinates: 1163879..1164136 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: LP102_RS05600
• Protein ID: WP_228157840.1
• Coordinates: 1163647..1163889 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP102_RS05565 (LP102_05520)	1158738..1159787	+	1050	WP_264676261.1	RluA family pseudouridine synthase	-
LP102_RS05570 (LP102_05525)	1159906..1160703	+	798	WP_264676861.1	polyphenol oxidase family protein	-
LP102_RS05575 (LP102_05530)	1160700..1161308	+	609	WP_264684677.1	bestrophin family protein	-
LP102_RS05580	1161589..1162112	+	524	Protein_1078	DUF853 family protein	-
LP102_RS05585 (LP102_05535)	1162099..1163046	+	948	WP_264676857.1	DUF853 domain-containing protein	-
LP102_RS05590 (LP102_05540)	1163069..1163356	+	288	WP_115005096.1	DUF1315 family protein	-
LP102_RS05595 (LP102_05545)	1163438..1163602	-	165	WP_158079593.1	hypothetical protein	-
LP102_RS05600 (LP102_05550)	1163647..1163889	+	243	WP_228157840.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
LP102_RS05605 (LP102_05555)	1163879..1164136	+	258	WP_264676856.1	Txe/YoeB family addiction module toxin	Toxin
LP102_RS05610 (LP102_05560)	1164195..1164704	+	510	WP_264676855.1	peptidylprolyl isomerase	-
LP102_RS05615 (LP102_05565)	1164771..1165574	+	804	WP_264676854.1	UDP-2,3-diacylglucosamine diphosphatase	-
LP102_RS05620 (LP102_05570)	1165671..1168157	-	2487	WP_264676853.1	alpha/beta hydrolase	-
LP102_RS05625 (LP102_05575)	1168260..1169108	-	849	WP_264676852.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-68)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10488.00 Da
• Isoelectric Point: 8.1158

>T226268 WP_264676856.1 NZ_CP087821:1163879-1164136 [Moraxella bovis]
MRIRWFDEVWEDYLYWQSQDKKTIKRINTLIKDCRRDPFDGIGKPEPLKYNLTGYWLRRINDANRLVYCCESETLIISCR
HHYEA

Nucleotide

• Length: 258 bp

>T226268 NZ_CP122328:1580005-1580358 [Pantoea agglomerans pv. betae]
GTGTGGATGATTAAAACGACGGAGAGGTTCGATCGCTGGTTTACCTTGCTTAATGAGAGCGATCGCGCCTGCGTACTGGC
AGCATTAATGGTGTTGCGCGAAAAAGGGCCGGGGTTGTCCAGGCCATACGCGGATACGTTAAAAGGCTCTGTTTATATCA
ACATGAAAGAGCTGCGTATTCAGAGTCGCGGTGATCCGATAAGGGCTTTCTTTGCTTTTGACCCAAACCGAACGGCGATT
GTGCTTTGTGCCGGAAATAAGGTGGGCAATGAAAAGCGTTTTTATCAGGAGATGCTTCCGGTTGCCGATCGGGAATTTAC
ACACTGGCTGAATAGTTTTAAAGATGAGGAGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9134.23 Da
• Isoelectric Point: 6.2120

>AT226268 WP_228157840.1 NZ_CP087821:1163647-1163889 [Moraxella bovis]
MNYSEFRQNLASALDYVQDSHAPVIVKRGKHSAVVISLDEYNAFKETDYLLSNPANAEHLMRGVQAVKNRQLTQRDLIED

Nucleotide

• Length: 243 bp

>AT226268 NZ_CP122328:1580363-1580665 [Pantoea agglomerans pv. betae]
ATGGGCAAAACGCTGGAACAGCTTATTGCGGATGAAAAACCGGAAGTCGTTGCCGACGCACAGGCGATGGCGACGGATAT
CCTGCTCAACATTCACCTTGCCGAGCTGCGTGAGAAAGTGCAGAAAACACAGGTCGAAATGGCAAAGGCGCTGGGCATTA
CACAGCCTACCGTGGCGGGCATGGAGAAGCCGGGCCGCGACCTGAAGCTCTCCACGCTCAAGCGCTACATCGATGCGGCA
GGGGGTAAGCTGCGGCTGGTGGTGGAACTGCCGGACGGCTCGCACTACGGGTTTGAGGTGTAA