Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2677024..2677682 Replicon chromosome
Accession NZ_CP087817
Organism Moraxella bovis strain SAM109237

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP109_RS13535 Protein ID WP_078274940.1
Coordinates 2677494..2677682 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP109_RS13530 Protein ID WP_112741846.1
Coordinates 2677024..2677431 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP109_RS13520 (LP109_13395) 2672659..2673054 - 396 WP_264676533.1 hypothetical protein -
LP109_RS13525 (LP109_13400) 2673133..2676948 - 3816 WP_264676534.1 phage tail tape measure protein -
LP109_RS13530 (LP109_13405) 2677024..2677431 - 408 WP_112741846.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP109_RS13535 (LP109_13410) 2677494..2677682 - 189 WP_078274940.1 type II toxin-antitoxin system HicA family toxin Toxin
LP109_RS13540 (LP109_13415) 2677824..2678039 - 216 WP_078274941.1 hypothetical protein -
LP109_RS13545 (LP109_13420) 2678041..2678640 - 600 WP_078274942.1 antA/AntB antirepressor family protein -
LP109_RS13550 (LP109_13425) 2678747..2678953 - 207 WP_078274943.1 hypothetical protein -
LP109_RS13555 (LP109_13430) 2679076..2679420 + 345 WP_078274944.1 helix-turn-helix transcriptional regulator -
LP109_RS13560 (LP109_13435) 2679464..2680216 - 753 WP_264676535.1 hypothetical protein -
LP109_RS13565 (LP109_13440) 2680283..2680609 - 327 WP_264676536.1 Gp49 family protein -
LP109_RS13570 (LP109_13445) 2680615..2680833 - 219 WP_264676537.1 hypothetical protein -
LP109_RS13575 (LP109_13450) 2680890..2681882 - 993 WP_264676538.1 major capsid protein -
LP109_RS13580 (LP109_13455) 2681922..2682278 - 357 WP_264676539.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2592678..2682290 89612


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-130)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7047.13 Da        Isoelectric Point: 10.3659

>T226264 WP_078274940.1 NZ_CP087817:c2677682-2677494 [Moraxella bovis]
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD

Download         Length: 189 bp

>T226264 NZ_CP122326:75874-76161 [Pantoea agglomerans pv. betae]
GTGAGTTATACCGTCAAATTCAGGGAAGAGGCTTTTAAAGAGTGGCAGAAGCTGGACAAATCTCTCCAGCAGCAGTTTGC
CAAAAAACTGAAGAAATGTTGTGACAATCCCCATATTCCTTCTGCCAGACTACGAGGGATTAAAGACTGCTATAAAATCA
AACTCAGAGCGTCCGGGTTTCGCCTGGTTTATCAGGTAATAGACGATCAACTGGTGATTGCCGTTGTTGCTGTGGGTAAA
CGCGAGCGCAGCGATGTTTATCATCTTGCCAGTGAGAGGATGCGGTAG

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14756.85 Da        Isoelectric Point: 4.2244

>AT226264 WP_112741846.1 NZ_CP087817:c2677431-2677024 [Moraxella bovis]
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG

Download         Length: 408 bp

>AT226264 NZ_CP122326:75626-75877 [Pantoea agglomerans pv. betae]
ATGCCAAACATTATTTTAAGCGATACCAGTGCCAGCGTAAGCGAACTGAAGAAAAACCCGATGGCCACGGTTAATGCAGG
TCACGGTTATCCTGTCGCCATTCTTAACCGCAACCAGCCTGCATTCTATTGCGTCCCGGCTGAGCTTTATGAACAGATGC
TTGATGCCCTTGACGATCAGGAACTGGTTAAGCTGGTCAGTGAACGCAGCGGCCAGCGTCTGCTTGATGTCGATTTGGAT
GCGCTTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References