Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2022037..2022692 Replicon chromosome
Accession NZ_CP087817
Organism Moraxella bovis strain SAM109237

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP109_RS10170 Protein ID WP_078274052.1
Coordinates 2022037..2022438 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP109_RS10175 Protein ID WP_078274053.1
Coordinates 2022453..2022692 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP109_RS10140 (LP109_10040) 2017778..2018101 + 324 WP_244893654.1 hypothetical protein -
LP109_RS10145 (LP109_10045) 2018118..2018537 + 420 WP_078274047.1 S4 domain-containing protein -
LP109_RS10155 (LP109_10055) 2019273..2019962 + 690 WP_078274049.1 SIMPL domain-containing protein -
LP109_RS10160 (LP109_10060) 2020061..2020891 - 831 WP_078274050.1 inositol monophosphatase family protein -
LP109_RS10165 (LP109_10065) 2021013..2021513 - 501 WP_078274051.1 WG repeat-containing protein -
LP109_RS10170 (LP109_10070) 2022037..2022438 - 402 WP_078274052.1 type II toxin-antitoxin system VapC family toxin Toxin
LP109_RS10175 (LP109_10075) 2022453..2022692 - 240 WP_078274053.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP109_RS10180 (LP109_10080) 2022735..2024834 - 2100 WP_078274054.1 1-deoxy-D-xylulose-5-phosphate synthase -
LP109_RS10185 (LP109_10085) 2025055..2025648 + 594 WP_208624078.1 GTP cyclohydrolase II -
LP109_RS10190 (LP109_10090) 2025668..2026660 + 993 WP_078274055.1 oxygen-dependent coproporphyrinogen oxidase -
LP109_RS10195 (LP109_10095) 2026842..2027291 + 450 WP_078274056.1 cytochrome c -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(10-56)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15131.33 Da        Isoelectric Point: 6.8510

>T226259 WP_078274052.1 NZ_CP087817:c2022438-2022037 [Moraxella bovis]
MFSFMLDTNIYIYVIKERPIKALNKFNQYAGRICVSSIVASELYFGAYNSQFMDKNLHQVEDFLSRLTVLDYTAECSPHY
GEICADLTKQGKLISENDIHIASHARALGLTLITNNTDEFKRVSGLRIGNWAI

Download         Length: 402 bp

>T226259 NZ_CP122322:c97689-97402 [Pantoea agglomerans pv. gypsophilae]
GTGAGTTATACCGTCAAATTCAGGGAAGAGGCTTTTAAAGAGTGGCAGAAGCTGGACAAATCTCTCCAGCAGCAGTTTGC
CAAAAAACTGAAGAAATGTTGTGATAATCCCCATATTCCTTCTGCCAGACTACGTGGGATTAAAGACTGCTATAAAATCA
AACTCAGAGCGTCCGGGTTTCGCCTGGTTTATCAGGTAATAGACGACCAGCTGGTGATTGCCGTTGTTGCTGTGGGTAAA
CGCGAGCGCAGCGATGTTTATCATCTTGCCAGTGAAAGGATGCGGTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9246.63 Da        Isoelectric Point: 7.9917

>AT226259 WP_078274053.1 NZ_CP087817:c2022692-2022453 [Moraxella bovis]
MPCKPVFFFNNRTQAVRIPAKFRFDDDVKAVMIRKVGNERILTPIDGVWDSFFLSDERASDDFMANRPTMPKSERLTFD

Download         Length: 240 bp

>AT226259 NZ_CP122322:c97937-97686 [Pantoea agglomerans pv. gypsophilae]
ATGCCAAACATTATTTTAAGCGATACCAGCGCCAGCGTAAGCGAACTGAAGAAAAACCCGATGGCCACGGTTAGTGCAGG
TGACGGTTATCCTGTCGCCATTCTTAACCGCAACCAGCCTGCATTCTATTGCGTCCCGGCTGAGCTTTATGAACAGATGC
TTGATGCCCTTGACGATCAGGAACTGGTTAAGCTGGTCAGTGAACGCAGCGGCCAGCGTCTGCTTGATGTCGATTTGGAT
GCGCTTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References