Detailed information of TA system TA226256

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): AbkB-shpB/BrnT-BrnA
• Location: 1718285..1718837
• Replicon: chromosome
• Accession: NZ_CP087817
• Organism: Moraxella bovis strain SAM109237

Toxin (Protein)

• Gene name: AbkB
• Uniprot ID: A0A1T0A7D3
• Locus tag: LP109_RS08490
• Protein ID: WP_029102268.1
• Coordinates: 1718285..1718563 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: -
• Locus tag: LP109_RS08495
• Protein ID: WP_078273473.1
• Coordinates: 1718550..1718837 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP109_RS08460 (LP109_08370)	1714273..1715049	-	777	WP_078273467.1	nucleotidyltransferase domain-containing protein	-
LP109_RS08465 (LP109_08375)	1715160..1715510	+	351	WP_078273468.1	TIGR01244 family sulfur transferase	-
LP109_RS08470 (LP109_08380)	1715658..1716173	+	516	WP_078273469.1	hypothetical protein	-
LP109_RS08475 (LP109_08385)	1716166..1716456	+	291	WP_078273470.1	hypothetical protein	-
LP109_RS08480 (LP109_08390)	1716669..1717334	+	666	WP_078273471.1	PspA/IM30 family protein	-
LP109_RS08485 (LP109_08395)	1717534..1718190	+	657	WP_078273472.1	YqiJ family protein	-
LP109_RS08490 (LP109_08400)	1718285..1718563	+	279	WP_029102268.1	BrnT family toxin	Toxin
LP109_RS08495 (LP109_08405)	1718550..1718837	+	288	WP_078273473.1	BrnA antitoxin family protein	Antitoxin
LP109_RS08500 (LP109_08410)	1718847..1720577	+	1731	WP_078273474.1	flotillin domain-containing protein	-
LP109_RS08505 (LP109_08415)	1720579..1720746	-	168	WP_158079604.1	hypothetical protein	-
LP109_RS08510 (LP109_08420)	1720775..1721809	-	1035	WP_143821647.1	DUF389 domain-containing protein	-
LP109_RS08515 (LP109_08425)	1721948..1722649	-	702	WP_078275358.1	IS1 family transposase	-
LP109_RS08520 (LP109_08430)	1722686..1723078	-	393	WP_264676432.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-85)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (36-89)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10484.81 Da
• Isoelectric Point: 5.1084

>T226256 WP_029102268.1 NZ_CP087817:1718285-1718563 [Moraxella bovis]
MIFEWDDNKNRTNKQKHGVSFESASRIFLDPFLIVTEDTSSDEVRWLGVGSVDGVVILLVVHTHTDTDGTEIIRIISARK
LSRGEIERYGYC

Nucleotide

• Length: 279 bp

>T226256 NZ_CP122321:160863-161333 [Pantoea agglomerans pv. gypsophilae]
ATGGAAGACAGCACGGTTATAAATGGATGGCACGTTTATGTTCATCCCTGTTTTGAATCGCAGCTGATTGCGCTGACCAA
TGAAGTGGAGTTACTCAGGGCTAAATATCCTGAAAGTTACCAGCGAAAAGCAACGACTAAGCTTTTAGCTGCTGTGTTTA
AAGTTATCAATAGTGAGATTTGCGCCGATCCACATCAGGCAAAGTTTCGCCAGGGCGATACGCTGGGAGAACAAAATAAG
CATTGGTTCCGTGCAAAGTTTTTGATGCAGTATCGTTTGTTCTTTAGATTCAGCGAGCAACATAAAACCATCATTCTTGC
ATGGATGAATGACGCTGAGACCAAACGTGCTTATGGCAGTAAGCGTGACGCCTATAAAGTATTTTCAGGAATGTTGCATA
ACGGCTATCCACCTGACGACTGGGCATTGCTGTTAAAGCAATCTCAGGATTGGGCGAAGATAAATTCTTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10979.71 Da
• Isoelectric Point: 7.0097

>AT226256 WP_078273473.1 NZ_CP087817:1718550-1718837 [Moraxella bovis]
MAIVRKTLDDIKHTPIDKDELAQLQSMSDDSINYDDIPPLTDVQIANLRLYKPIKQQITLRLDSDIVAWLKKDGKGYQTR
ANQLLRQLMLKELTT

Nucleotide

• Length: 288 bp

>AT226256 NZ_CP122321:160512-160856 [Pantoea agglomerans pv. gypsophilae]
ATGGGAACTCTGACTCATGCAAACATCTCTCTGCGTGCTTCATCAAAACTGACAGCGCGCAGCCAGACCACTATCCCTGC
CGCAGTTCGTGATGCGATGAATCTGCAGCCTGGTGAGAATATCGAATACGCTGTTCTGCCGGGCGGCAAAGTCCTTATTA
CCCGTCAGGAAACGGTGACTGATGATGATCCAGTGATGGCGAGCTTTCTGAGTTTTCTTGCTGCTGACATACGCAACACA
CCTGCAAATATTAAAACGCTGGATCGAGGATTATTAACTCGCATTACATCGTTGACCGAAGGTATGGACGTTGATTTGGA
TGCTCCACTCATGGACGATGAGTAA

Structures

Toxin

• AlphaFold DB: A0A1T0A7D3