Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 606339..606882 Replicon chromosome
Accession NZ_CP087817
Organism Moraxella bovis strain SAM109237

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP109_RS03015 Protein ID WP_244893652.1
Coordinates 606655..606882 (-) Length 76 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP109_RS03010 Protein ID WP_078273964.1
Coordinates 606339..606674 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP109_RS02990 (LP109_02975) 601499..602581 - 1083 WP_078273961.1 tRNA pseudouridine(13) synthase TruD -
LP109_RS02995 (LP109_02980) 602715..603482 - 768 WP_078273962.1 carbonic anhydrase family protein -
LP109_RS03000 (LP109_02985) 604128..605309 - 1182 WP_078274027.1 fatty acid desaturase -
LP109_RS03005 (LP109_02990) 605571..606155 + 585 Protein_578 TetR/AcrR family transcriptional regulator -
LP109_RS03010 (LP109_02995) 606339..606674 - 336 WP_078273964.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP109_RS03015 (LP109_03000) 606655..606882 - 228 WP_244893652.1 hypothetical protein Toxin
LP109_RS03020 (LP109_03005) 607114..607821 + 708 WP_078273965.1 ParA family protein -
LP109_RS03025 (LP109_03010) 607911..609296 - 1386 WP_078273966.1 APC family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 76 a.a.        Molecular weight: 8474.22 Da        Isoelectric Point: 4.7513

>T226255 WP_244893652.1 NZ_CP087817:c606882-606655 [Moraxella bovis]
ISERAGSRMAVALNGQVMVFHRPHPSPNTDKSAVMSIRKWLDGMGITPLDDDSQTDEYADKQTDEQEQTHEHHDN

Download         Length: 228 bp

>T226255 NZ_CP122320:c3557928-3557575 [Pantoea agglomerans pv. gypsophilae]
GTGTGGATGATTAAAACGACGGAGAGGTTTGATCGCTGGTTTACCTTGCTTAATGAGAGCGATCGCGCCTGCGTACTGGC
AGCATTAATGGTGTTGCGCGAAAAGGGGCCGGGGTTGTCCAGGCCATACGCGGATACTCTAAAAGGCTCTGTTTATATCA
ACATGAAAGAGCTGCGTATTCAGAGTCGCGGCGATCCGATTAGGGCTTTCTTTGCTTTTGACCCAAACCGAACGGCGATT
GTGCTTTGTGCCGGAAATAAGATGGGCAATGAAAAGCGTTTTTATCAGGAGATGCTTCCGGTTGCCGATCGGGAATTTAC
ACACTGGCTGAATAGCTTTAAAGATGAGGAGTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12189.67 Da        Isoelectric Point: 4.5658

>AT226255 WP_078273964.1 NZ_CP087817:c606674-606339 [Moraxella bovis]
MNTMTINNHKALITFDSELGLFRGEFIGLNGGADFYADSVDGLNEQGALSLQAFLDVCQEQGISPYQSYSGKFVTRLPKE
LHQKIAETATAKGISLNQWINETLSREVGFA

Download         Length: 336 bp

>AT226255 NZ_CP122320:c3557570-3557268 [Pantoea agglomerans pv. gypsophilae]
ATGGGCAGAACGCTTGAACAGCTTATTGCGGATGAAAAACCGGAAGTCGTTGCCGACGCACAAGCGATGGCGACGGATAT
CCTGCTCAACATTCACCTTGCCGAGCTGCGTGAGAAAGTGCAGAAAACACAGGTCGAAATGGCAAAGGCGCTGGGCATTA
CACAGCCTACCGTGGCGGGTATGGAAAAGCCGGGCCGCGATCTGAAGCTCTCCACGCTCAAGCGCTATATCGATGCGGCA
GGGGGTAAGCTGCGGCTGGTGGTGGAACTGCCGGACGGCTCGCACTACGGGTTTGAGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References