Detailed information of TA system TA226254

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 29063..29721
• Replicon: chromosome
• Accession: NZ_CP087817
• Organism: Moraxella bovis strain SAM109237

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LP109_RS00130
• Protein ID: WP_078274940.1
• Coordinates: 29533..29721 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LP109_RS00125
• Protein ID: WP_112741846.1
• Coordinates: 29063..29470 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP109_RS00110 (LP109_00115)	24150..24653	-	504	WP_264676562.1	hypothetical protein	-
LP109_RS00115 (LP109_00120)	24698..25093	-	396	WP_264676533.1	hypothetical protein	-
LP109_RS00120 (LP109_00125)	25172..28987	-	3816	WP_264676534.1	phage tail tape measure protein	-
LP109_RS00125 (LP109_00130)	29063..29470	-	408	WP_112741846.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LP109_RS00130 (LP109_00135)	29533..29721	-	189	WP_078274940.1	type II toxin-antitoxin system HicA family toxin	Toxin
LP109_RS00135 (LP109_00140)	29863..30012	-	150	WP_264676563.1	hypothetical protein	-
LP109_RS00140 (LP109_00145)	30181..30528	-	348	WP_078274950.1	hypothetical protein	-
LP109_RS00145 (LP109_00150)	30551..30739	+	189	WP_078274951.1	hypothetical protein	-
LP109_RS00150 (LP109_00155)	30720..30911	-	192	WP_078274952.1	hypothetical protein	-
LP109_RS00155 (LP109_00160)	30914..31243	-	330	WP_078274953.1	hypothetical protein	-
LP109_RS00160 (LP109_00165)	31249..32589	-	1341	WP_158079697.1	phage minor head protein	-
LP109_RS00165 (LP109_00170)	32591..33487	-	897	WP_158079698.1	hypothetical protein	-
LP109_RS00170 (LP109_00175)	33394..34113	-	720	WP_078274956.1	DUF2786 domain-containing protein	-
LP109_RS00175 (LP109_00180)	34206..34439	-	234	WP_078274957.1	ANR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2675..47197	44522

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-61)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-130)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7047.13 Da
• Isoelectric Point: 10.3659

>T226254 WP_078274940.1 NZ_CP087817:c29721-29533 [Moraxella bovis]
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD

Nucleotide

• Length: 189 bp

>T226254 NZ_CP122320:3371511-3371828 [Pantoea agglomerans pv. gypsophilae]
GTGGCAACGTTAAGGAATATTGAAAGTTTCAGGGATGACTGGCTTAAGGATTATTTTTTATATGGCAAATTTTCCAAAAG
AATACCGTCAAGCCTCTCATCAGCGCTGGCGCGAAAGCTCGACATCATCAATGCGGCGATTAGCTATAAGGATTTAAAGT
CGCCGCCAGGCAATCGTTATGAGGAACTAAACCCGCCTCTCAAGGGATATGCTTCAATCAGGGTCAATGAGCAATATCGG
CTGATCTTTAAATGGATAGAAGGTAAGGCCGTTGACCTTTATCTGGATGCTCATAGTTATAAAACGCACAAGCGATGA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14756.85 Da
• Isoelectric Point: 4.2244

>AT226254 WP_112741846.1 NZ_CP087817:c29470-29063 [Moraxella bovis]
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG

Nucleotide

• Length: 408 bp

>AT226254 NZ_CP122320:3371909-3372241 [Pantoea agglomerans pv. gypsophilae]
ATGAACCAGGCGACCCGCAAACCGACCACTGTCGGTGACGTATTACTTTACGAATATCTGGAGCCAACCGGCCTGAAGAT
TCTCGACTTAGCGGAGATGCTCAAAGTGCACCGCAACACCGTCAGCGCTCTGGTCAACAATAACCGGAAGCTGACGCCGG
ATATGGCTTTCAGGCTGGCTGCAGCTTTCGAAACCAGCGTTGAGTTCTGGCTTAATCTGCAAAACAGTGTCGATATCTGG
GAAGTGATGCATGATGCCAGGGCACAGGAGGAGATCAGTCGCGTAACACCGTTGAAGGATTTTCTGGCGCAGAAAGAGAA
TCAGCTGGCGTGA