Detailed information of TA system TA226252

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 2318573..2319131
• Replicon: chromosome
• Accession: NZ_CP087814
• Organism: Moraxella bovis strain SAM109238

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LP088_RS11835
• Protein ID: WP_228157760.1
• Coordinates: 2318573..2318845 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1S9ZVK6
• Locus tag: LP088_RS11840
• Protein ID: WP_029103533.1
• Coordinates: 2318838..2319131 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP088_RS11795 (LP088_11680)	2313787..2314023	+	237	WP_078275185.1	sulfurtransferase TusA	-
LP088_RS11800 (LP088_11685)	2314026..2314592	+	567	WP_078275186.1	hypothetical protein	-
LP088_RS11805 (LP088_11690)	2314589..2315119	-	531	WP_078275187.1	HI_0552 family protein	-
LP088_RS11810 (LP088_11695)	2315242..2315634	-	393	WP_078275188.1	type II toxin-antitoxin system VapC family toxin	-
LP088_RS11815 (LP088_11700)	2315631..2315894	-	264	WP_264675982.1	type II toxin-antitoxin system VapB family antitoxin	-
LP088_RS11820 (LP088_11705)	2315974..2317233	-	1260	WP_264675983.1	replication-associated recombination protein A	-
LP088_RS11825 (LP088_11710)	2317591..2317968	-	378	WP_264675984.1	hypothetical protein	-
LP088_RS11830 (LP088_11715)	2318053..2318508	+	456	WP_264675985.1	type IV secretion protein Rhs	-
LP088_RS11835 (LP088_11720)	2318573..2318845	-	273	WP_228157760.1	type II toxin-antitoxin system YafQ family toxin	Toxin
LP088_RS11840 (LP088_11725)	2318838..2319131	-	294	WP_029103533.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LP088_RS11845 (LP088_11730)	2319275..2320609	-	1335	WP_112741795.1	deoxyguanosinetriphosphate triphosphohydrolase	-
LP088_RS11850 (LP088_11735)	2320818..2321534	-	717	WP_078275193.1	hypothetical protein	-
LP088_RS11855 (LP088_11740)	2321555..2322166	-	612	WP_112741794.1	methyltransferase	-
LP088_RS11860 (LP088_11745)	2322286..2323620	+	1335	WP_078275195.1	valine--pyruvate transaminase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (6-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-67)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10415.99 Da
• Isoelectric Point: 6.9668

>T226252 WP_228157760.1 NZ_CP087814:c2318845-2318573 [Moraxella bovis]
VAKRSFEMGNPFKRDLKKHYLALIGEAWTEVSDCLLNAKPIPQKYQDHPLQGDWVGFRDCHIKPDLVLIYKINDEAVELH
RLATHSELFG

Nucleotide

• Length: 273 bp

>T226252 NZ_CP122320:c2231596-2231285 [Pantoea agglomerans pv. gypsophilae]
ATGTTATTCATTGAGACTCCTGTATTCACGGAAGATGTAAAGGAACTACTCAGCGATGATGAATATCGCGAGTTTCAACA
ATTCATGGCTGACAATCCAGGCTGGGGTGATGTTATCCAGAATACGGGTGGCCTGCGTAAAGTGCGCTGGGCGGCCAAAG
GCAAAGGTAAGCGTGGCGGCGTTCGGGTGATTTACTATTACAAAGTCTCTGAATCACAAATCAGGCTGTTGCTGATTTAT
AAAAAAGGCGTCCAGGATGATTTATCCGAGGATGAAAAACATCTGTTAAGGGCGTTGAACGAGGGCTGGTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11068.31 Da
• Isoelectric Point: 4.7769

>AT226252 WP_029103533.1 NZ_CP087814:c2319131-2318838 [Moraxella bovis]
MSHTNFNMRLDNDLRQKAYPVLEQYGLTPSQAVRMFFNQIAQTGKVPLSFDWGQSHTLSSNGEKLLRESIQAFENGETER
FDSLDELNQAMAEIARG

Nucleotide

• Length: 294 bp

>AT226252 NZ_CP122320:c2231285-2230992 [Pantoea agglomerans pv. gypsophilae]
ATGGACAAAAAACTGTTTGAGCGTTTGAAAGAAAGCATGACTCAGATGAATGAGATCGTCGAAGGCTCCCGAGCACCTGC
CCGCGAAAGCACAGTCACTGCGGTTAAAGTCAAAGCTATCAGAAACGCTACTGGTCTTTCGCAAAGCGGGTTCGCTAAGC
TGATTTCCGTGAATGTAGACACGCTAAAAAACTGGGAGCAGGGACGACGTGAGCCAACCGGCCCGGCTAAAGCTTTACTC
CGGGCCATAGAACGCGATCCGCAGCATGTGATCCCAGCGCTTGCTGATAAATAA

Structures

Antitoxin

• AlphaFold DB: A0A1S9ZVK6