Detailed information of TA system TA226251

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2315242..2315894
• Replicon: chromosome
• Accession: NZ_CP087814
• Organism: Moraxella bovis strain SAM109238

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LP088_RS11810
• Protein ID: WP_078275188.1
• Coordinates: 2315242..2315634 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LP088_RS11815
• Protein ID: WP_264675982.1
• Coordinates: 2315631..2315894 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP088_RS11775 (LP088_11660)	2310334..2311275	+	942	WP_078275181.1	hydroxymethylbilane synthase	-
LP088_RS11780 (LP088_11665)	2311321..2312199	+	879	WP_112741796.1	uroporphyrinogen-III synthase	-
LP088_RS11785 (LP088_11670)	2312230..2313252	+	1023	WP_078275183.1	hypothetical protein	-
LP088_RS11790 (LP088_11675)	2313332..2313790	+	459	WP_078275184.1	acyl-CoA thioesterase	-
LP088_RS11795 (LP088_11680)	2313787..2314023	+	237	WP_078275185.1	sulfurtransferase TusA	-
LP088_RS11800 (LP088_11685)	2314026..2314592	+	567	WP_078275186.1	hypothetical protein	-
LP088_RS11805 (LP088_11690)	2314589..2315119	-	531	WP_078275187.1	HI_0552 family protein	-
LP088_RS11810 (LP088_11695)	2315242..2315634	-	393	WP_078275188.1	type II toxin-antitoxin system VapC family toxin	Toxin
LP088_RS11815 (LP088_11700)	2315631..2315894	-	264	WP_264675982.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
LP088_RS11820 (LP088_11705)	2315974..2317233	-	1260	WP_264675983.1	replication-associated recombination protein A	-
LP088_RS11825 (LP088_11710)	2317591..2317968	-	378	WP_264675984.1	hypothetical protein	-
LP088_RS11830 (LP088_11715)	2318053..2318508	+	456	WP_264675985.1	type IV secretion protein Rhs	-
LP088_RS11835 (LP088_11720)	2318573..2318845	-	273	WP_228157760.1	type II toxin-antitoxin system YafQ family toxin	-
LP088_RS11840 (LP088_11725)	2318838..2319131	-	294	WP_029103533.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
LP088_RS11845 (LP088_11730)	2319275..2320609	-	1335	WP_112741795.1	deoxyguanosinetriphosphate triphosphohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-122)

Antitoxin

• SpoVT-AbrB domain (10-50)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14689.79 Da
• Isoelectric Point: 4.7370

>T226251 WP_078275188.1 NZ_CP087814:c2315634-2315242 [Moraxella bovis]
MKYLLDTNAVIAILNASERFLTTLERHKEREIAISSIVLSELYYGAYKSQKTAQNLEKINLLPFEVLQFNSQDADKAGEI
GATLERRGTPIGFYDTLIAGQAIANDLIVITDNVREFLRVDGLQIENWLK

Nucleotide

• Length: 393 bp

>T226251 NZ_CP122320:c1991685-1991470 [Pantoea agglomerans pv. gypsophilae]
ATGAACAAAACCCTGACTAAAACCGATTATTTGATGCGACTGCGGCGCTGCCGCTCTCTTGATACCCTGGAAAGGGTGAT
TGAAAAAAATAAGTATGAATTACCGGAAGATGAATTAGCGGTATTTTACTCAGCAGCTGACCATCGCCTGGCGGAACTGA
CGATGAACAAGCTCTACGATAAAGTCCCGGGTTCAGTATGGAAATTTGTCCGTTAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10153.49 Da
• Isoelectric Point: 6.3724

>AT226251 WP_264675982.1 NZ_CP087814:c2315894-2315631 [Moraxella bovis]
MRQTATAKLFWTGNSQAVRLPKAFRFEGTEVRIKKQGRQVIIEPAETQDWAWLDKLRAMPKDDSFEEAILEGRQNLKADE
RDWGAFE

Nucleotide

• Length: 264 bp

>AT226251 NZ_CP122320:c1992087-1991710 [Pantoea agglomerans pv. gypsophilae]
ATGGACGAATACTCACCGAAACGGCATGATATTGCCCAGCTTAAATACCTTTGTGAGAGTCTGTTTGACGACAGCATGGC
AACATTAACCGACAGTCATCATGGCTGGGTTAATGATCCCACTTCTGAAAGCAATCTACAGCTTAACGATTTGATTGAGC
ATATCGCCTCTTTCACCATGAATTACAAAATTAAGCACGTTGAAGATGAAGCGCTGATTTCGCAAATCGATGAATATCTT
GATGATACTTTTATGCTATTCAGCAATTATGGTGTCAATAGTCCGGATCTTCAGCGGTGGCAACGTTCAGCAAAACGCTT
ATTTAATCTGTTCACTGAAGAGTGCGCTTTTCTCCAGCAACCGAGCCATTCATTATAG