Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2082921..2083497 Replicon chromosome
Accession NZ_CP087814
Organism Moraxella bovis strain SAM109238

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP088_RS10605 Protein ID WP_264676341.1
Coordinates 2082921..2083181 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP088_RS10610 Protein ID WP_078273964.1
Coordinates 2083162..2083497 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP088_RS10590 (LP088_10500) 2077952..2080027 + 2076 WP_264675941.1 NAD-dependent DNA ligase LigA -
LP088_RS10595 (LP088_10505) 2080540..2081925 + 1386 WP_078273966.1 APC family permease -
LP088_RS10600 (LP088_10510) 2082015..2082722 - 708 WP_264675942.1 ParA family protein -
LP088_RS10605 (LP088_10515) 2082921..2083181 + 261 WP_264676341.1 type II toxin-antitoxin system HicA family toxin Toxin
LP088_RS10610 (LP088_10520) 2083162..2083497 + 336 WP_078273964.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP088_RS10615 (LP088_10525) 2083681..2084265 - 585 Protein_2077 TetR/AcrR family transcriptional regulator -
LP088_RS10620 (LP088_10530) 2084527..2085708 + 1182 WP_078274027.1 fatty acid desaturase -
LP088_RS10625 (LP088_10535) 2086354..2087121 + 768 WP_112742541.1 carbonic anhydrase family protein -
LP088_RS10630 (LP088_10540) 2087255..2088337 + 1083 WP_078273961.1 tRNA pseudouridine(13) synthase TruD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9551.46 Da        Isoelectric Point: 4.3376

>T226250 WP_264676341.1 NZ_CP087814:2082921-2083181 [Moraxella bovis]
IEALFVALGADISERAGSRMAVALNGQVMVFHRPHPSPNTDKSAVMSIRKWLDGMGITPLDDDSQTDEYADKQTDEQEQT
HEHNDN

Download         Length: 261 bp

>T226250 NZ_CP122320:1727880-1728059 [Pantoea agglomerans pv. gypsophilae]
ATGGATAGCAGCACGTTAATTTCCGAAATGAAGGCTGATGGCTGGGTTCTGACAGGGATAAACGGTAGCCATCACCATTT
CACACATCCGACAAAACCGGGGCTGGTTACAGTACCCCATCCTAAAAAAGACTTACCGATCGGTACGGTAAAGAGCATCA
GGAAACAAGCGAGAATTTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12189.67 Da        Isoelectric Point: 4.5658

>AT226250 WP_078273964.1 NZ_CP087814:2083162-2083497 [Moraxella bovis]
MNTMTINNHKALITFDSELGLFRGEFIGLNGGADFYADSVDGLNEQGALSLQAFLDVCQEQGISPYQSYSGKFVTRLPKE
LHQKIAETATAKGISLNQWINETLSREVGFA

Download         Length: 336 bp

>AT226250 NZ_CP122320:1728086-1728511 [Pantoea agglomerans pv. gypsophilae]
ATGTTTTATCCAATCGCGATTGAAGCGGGTGATCACGAACACGCATACGGCGTAATCGTTCCCGATTTACCAGGGTGTTT
CTCTGCCGGGGATACTCTTGATGAAGCCATTAAAAACGCCAAAGAGGCTATCACAGGGCATATCGAATTATGTGTAGAAC
TCGGTCATGAGATCCCTGCCGTGTCCACCATTGAGACTCTGGCCACGAATCTTGAATATCAGGGTTATATCTGGGCATTG
GTTGATGTAGATGTCATTCGCTTGCTGGGCGGCTCTGAAAAAATCAATGTCACTTTACCCAGGTCGTTAATTGATCGGAT
TGATCGTTGTGTGGCTTCACACCCGGAATACAAAAGTCGCTCGGGCTTTCTGGCTCAGGTAGCGCTTGAGCGTATTACTG
CTCCGATTAACAGGCCTCAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References