22625

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-UPF0150
Location 791936..792369 Replicon chromosome
Accession NC_010296
Organism Microcystis aeruginosa NIES-843

Toxin (Protein)


Gene name hicA Uniprot ID B0JRI6
Locus tag MAE_RS04030 Protein ID WP_012264433.1
Coordinates 792145..792369 (+) Length 75 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID I4IBE8
Locus tag MAE_RS04025 Protein ID WP_008199545.1
Coordinates 791936..792148 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MAE_RS04000 789506..789961 + 456 Protein_817 PEP-CTERM sorting domain-containing protein -
MAE_RS04005 790655..790927 - 273 WP_012264430.1 Txe/YoeB family addiction module toxin -
MAE_RS04010 790911..791210 - 300 WP_002763657.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MAE_RS04015 791354..791692 + 339 WP_012264431.1 hypothetical protein -
MAE_RS04020 791683..791868 + 186 WP_041803782.1 hypothetical protein -
MAE_RS04025 791936..792148 + 213 WP_008199545.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MAE_RS04030 792145..792369 + 225 WP_012264433.1 type II toxin-antitoxin system HicA family toxin Toxin
MAE_RS04035 792447..792719 + 273 WP_012264434.1 hypothetical protein -
MAE_RS04040 792777..792977 + 201 WP_008199548.1 hypothetical protein -
MAE_RS04045 793083..793328 + 246 WP_002753457.1 type II toxin-antitoxin system HicB family antitoxin -
MAE_RS04050 793328..793549 + 222 WP_002732388.1 type II toxin-antitoxin system HicA family toxin -
MAE_RS04055 793646..795082 - 1437 WP_012264436.1 folate/biopterin family MFS transporter -
MAE_RS04060 796466..797080 - 615 Protein_829 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(9-65)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-62)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8427.96 Da        Isoelectric Point: 11.2578

>T22625 WP_012264433.1 NC_010296:792145-792369 [Microcystis aeruginosa NIES-843]
MSELPPIAGRQVVKALGKIGYELDRQRGSHIILRQKAYPYRRITIPDHREVAKGTLRSIIRQAGLTMAEFKTLL

Download         Length: 225 bp

>T22625 NC_010296:792145-792369 [Microcystis aeruginosa NIES-843]
ATGAGTGAACTCCCTCCTATCGCTGGTCGCCAAGTCGTTAAAGCACTGGGCAAGATTGGCTACGAATTAGATCGGCAGCG
AGGAAGTCATATCATACTCAGACAAAAAGCCTATCCCTATCGACGCATCACCATCCCTGACCATCGAGAAGTGGCTAAGG
GAACACTGAGATCTATCATTCGTCAAGCGGGATTGACAATGGCAGAGTTTAAAACTCTCCTTTAG

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7836.95 Da        Isoelectric Point: 3.9098

>AT22625 WP_008199545.1 NC_010296:791936-792148 [Microcystis aeruginosa NIES-843]
MKYRVLIEQDEDGIYVAEVPSLPGCISQGNTRFELLANIQEAIALYLESLEAHNEPIPPPISEELVEVKL

Download         Length: 213 bp

>AT22625 NC_010296:791936-792148 [Microcystis aeruginosa NIES-843]
ATGAAATATCGCGTCTTAATTGAGCAAGATGAAGATGGCATTTATGTGGCTGAAGTTCCCTCCCTACCCGGCTGTATTTC
TCAAGGCAATACCCGGTTCGAGTTACTCGCCAACATTCAGGAAGCAATTGCTTTATATCTAGAAAGCCTAGAAGCGCACA
ATGAACCGATTCCACCACCAATTTCTGAGGAACTGGTAGAGGTTAAATTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G9JPA5

Antitoxin

Source ID Structure
AlphaFold DB I4IBE8

References