Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicB(antitoxin) |
| Location | 1276940..1277597 | Replicon | chromosome |
| Accession | NZ_CP087814 | ||
| Organism | Moraxella bovis strain SAM109238 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | LP088_RS06790 | Protein ID | WP_264676287.1 |
| Coordinates | 1277415..1277597 (-) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | LP088_RS06785 | Protein ID | WP_264676286.1 |
| Coordinates | 1276940..1277353 (-) | Length | 138 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LP088_RS06730 (LP088_06685) | 1272058..1272333 | + | 276 | WP_112742261.1 | YdaS family helix-turn-helix protein | - |
| LP088_RS06735 (LP088_06690) | 1272401..1273084 | + | 684 | WP_264676189.1 | Rha family transcriptional regulator | - |
| LP088_RS06740 (LP088_06695) | 1273081..1273968 | + | 888 | WP_264690424.1 | replication protein | - |
| LP088_RS06745 (LP088_06700) | 1273965..1274573 | + | 609 | WP_078273440.1 | hypothetical protein | - |
| LP088_RS06750 (LP088_06705) | 1274570..1274965 | + | 396 | WP_264676281.1 | VRR-NUC domain-containing protein | - |
| LP088_RS06755 (LP088_06710) | 1274962..1275240 | + | 279 | WP_264676282.1 | hypothetical protein | - |
| LP088_RS06760 (LP088_06715) | 1275262..1275552 | + | 291 | WP_112742084.1 | hypothetical protein | - |
| LP088_RS06765 (LP088_06720) | 1275549..1276034 | + | 486 | WP_078273444.1 | recombination protein NinB | - |
| LP088_RS06770 (LP088_06725) | 1276171..1276326 | + | 156 | WP_264676283.1 | hypothetical protein | - |
| LP088_RS06775 (LP088_06730) | 1276323..1276544 | + | 222 | WP_264676284.1 | DUF3310 domain-containing protein | - |
| LP088_RS06780 (LP088_06735) | 1276528..1276929 | + | 402 | WP_264676285.1 | antiterminator Q family protein | - |
| LP088_RS06785 (LP088_06740) | 1276940..1277353 | - | 414 | WP_264676286.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| LP088_RS06790 (LP088_06745) | 1277415..1277597 | - | 183 | WP_264676287.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| LP088_RS06795 (LP088_06750) | 1277997..1278701 | + | 705 | WP_264676288.1 | BRO family protein | - |
| LP088_RS06800 (LP088_06755) | 1279128..1279328 | - | 201 | WP_264676289.1 | helix-turn-helix domain-containing protein | - |
| LP088_RS06805 (LP088_06760) | 1279365..1279574 | - | 210 | WP_264676290.1 | hypothetical protein | - |
| LP088_RS06810 (LP088_06765) | 1279688..1280227 | + | 540 | WP_264676291.1 | terminase small subunit | - |
| LP088_RS06815 (LP088_06770) | 1280227..1281624 | + | 1398 | WP_264676292.1 | phage terminase large subunit | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1258490..1306906 | 48416 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6761.81 Da Isoelectric Point: 10.7622
>T226249 WP_264676287.1 NZ_CP087814:c1277597-1277415 [Moraxella bovis]
MKYSEFQRWLLAQGATVNKQGGKGSHRKVTLNGKTTTFPYHGSKEIGEGLRKKILKDLDL
MKYSEFQRWLLAQGATVNKQGGKGSHRKVTLNGKTTTFPYHGSKEIGEGLRKKILKDLDL
Download Length: 183 bp
>T226249 NZ_CP122320:1546319-1546648 [Pantoea agglomerans pv. gypsophilae]
ATGACTGACGCCCATTCTATTGCACAACTGTCTGAACCAGAAGTCTCTCCTGCAGATAACCGGCAATTAACCGTTAGCTA
TGCAAGCCGCTATCCGGATTACAGCCGGATACCCGCCATCACCATGAAAGGACAATGGCTGGAAGCTGCCGGTTTTGCTA
CTGGCACAGCAGTAGATGTAAAGGTAATGGAGGGTTGTATTGTGCTCACCGCCCGACTGGAGAGCGAACTGATGCAGTCG
CTGCGCCAGGTATGCAAGCTGTCGGCGCGGAAACAAAAGCAGGTGCAGGAGTTTATTCAGGTTATATCCGGTAAACAGAA
AGTCGTCTGA
ATGACTGACGCCCATTCTATTGCACAACTGTCTGAACCAGAAGTCTCTCCTGCAGATAACCGGCAATTAACCGTTAGCTA
TGCAAGCCGCTATCCGGATTACAGCCGGATACCCGCCATCACCATGAAAGGACAATGGCTGGAAGCTGCCGGTTTTGCTA
CTGGCACAGCAGTAGATGTAAAGGTAATGGAGGGTTGTATTGTGCTCACCGCCCGACTGGAGAGCGAACTGATGCAGTCG
CTGCGCCAGGTATGCAAGCTGTCGGCGCGGAAACAAAAGCAGGTGCAGGAGTTTATTCAGGTTATATCCGGTAAACAGAA
AGTCGTCTGA
Antitoxin
Download Length: 138 a.a. Molecular weight: 15339.53 Da Isoelectric Point: 4.7523
>AT226249 WP_264676286.1 NZ_CP087814:c1277353-1276940 [Moraxella bovis]
MYYPATFTPDTNDTFLVAFRDIPEAVGVGETFEIAYQSALDGLETAFSIYMDERKPIPAPSELSDGEHAIYLPVAVQTKL
ALYHEMLAQGVTKAELARRLSVNQKQIDRLWDVSHSTKLEFLEKAFSVLGKRLSLAI
MYYPATFTPDTNDTFLVAFRDIPEAVGVGETFEIAYQSALDGLETAFSIYMDERKPIPAPSELSDGEHAIYLPVAVQTKL
ALYHEMLAQGVTKAELARRLSVNQKQIDRLWDVSHSTKLEFLEKAFSVLGKRLSLAI
Download Length: 414 bp
>AT226249 NZ_CP122320:c1546324-1546248 [Pantoea agglomerans pv. gypsophilae]
AGTCATGATTACTATTCTCCGTAAATAGTGATTGTGATTAGCGGCGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
AGTCATGATTACTATTCTCCGTAAATAGTGATTGTGATTAGCGGCGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|