Detailed information of TA system TA226247

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): AbkB-shpB/BrnT-BrnA
• Location: 956139..956691
• Replicon: chromosome
• Accession: NZ_CP087814
• Organism: Moraxella bovis strain SAM109238

Toxin (Protein)

• Gene name: AbkB
• Uniprot ID: A0A1T0A7D3
• Locus tag: LP088_RS05105
• Protein ID: WP_029102268.1
• Coordinates: 956413..956691 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: -
• Locus tag: LP088_RS05100
• Protein ID: WP_078273473.1
• Coordinates: 956139..956426 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP088_RS05080 (LP088_05065)	951574..952623	+	1050	WP_264676228.1	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	-
LP088_RS05085 (LP088_05070)	952702..954201	+	1500	WP_264690421.1	DUF389 domain-containing protein	-
LP088_RS05090	954230..954355	+	126	WP_264676709.1	hypothetical protein	-
LP088_RS05095 (LP088_05075)	954399..956129	-	1731	WP_078273474.1	flotillin domain-containing protein	-
LP088_RS05100 (LP088_05080)	956139..956426	-	288	WP_078273473.1	BrnA antitoxin family protein	Antitoxin
LP088_RS05105 (LP088_05085)	956413..956691	-	279	WP_029102268.1	BrnT family toxin	Toxin
LP088_RS05110 (LP088_05090)	956786..957442	-	657	WP_078273472.1	YqiJ family protein	-
LP088_RS05115 (LP088_05095)	957642..958307	-	666	WP_078273471.1	PspA/IM30 family protein	-
LP088_RS05120 (LP088_05100)	958520..958810	-	291	WP_264676229.1	hypothetical protein	-
LP088_RS05125 (LP088_05105)	958803..959318	-	516	WP_115369660.1	hypothetical protein	-
LP088_RS05130 (LP088_05110)	959466..959816	-	351	WP_078273468.1	TIGR01244 family sulfur transferase	-
LP088_RS05135 (LP088_05115)	959928..960704	+	777	WP_264676230.1	nucleotidyltransferase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-85)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (36-89)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10484.81 Da
• Isoelectric Point: 5.1084

>T226247 WP_029102268.1 NZ_CP087814:c956691-956413 [Moraxella bovis]
MIFEWDDNKNRTNKQKHGVSFESASRIFLDPFLIVTEDTSSDEVRWLGVGSVDGVVILLVVHTHTDTDGTEIIRIISARK
LSRGEIERYGYC

Nucleotide

• Length: 279 bp

>T226247 NZ_CP122319:c4524788-4524537 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10979.71 Da
• Isoelectric Point: 7.0097

>AT226247 WP_078273473.1 NZ_CP087814:c956426-956139 [Moraxella bovis]
MAIVRKTLDDIKHTPIDKDELAQLQSMSDDSINYDDIPPLTDVQIANLRLYKPIKQQITLRLDSDIVAWLKKDGKGYQTR
ANQLLRQLMLKELTT

Nucleotide

• Length: 288 bp

>AT226247 NZ_CP122319:c4524540-4524286 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Toxin

• AlphaFold DB: A0A1T0A7D3