Detailed information of TA system TA226245

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 743942..744519
• Replicon: chromosome
• Accession: NZ_CP087814
• Organism: Moraxella bovis strain SAM109238

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LP088_RS03925
• Protein ID: WP_078275234.1
• Coordinates: 744184..744519 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LP088_RS03920
• Protein ID: WP_078275235.1
• Coordinates: 743942..744184 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP088_RS03895 (LP088_03885)	739841..740263	-	423	WP_078275239.1	hypothetical protein	-
LP088_RS03900 (LP088_03890)	740272..740577	-	306	WP_078275238.1	YciI family protein	-
LP088_RS03905 (LP088_03895)	740737..741363	-	627	WP_078275237.1	septation protein IspZ	-
LP088_RS03910 (LP088_03900)	741552..742274	+	723	WP_078275236.1	tRNA pseudouridine(65) synthase TruC	-
LP088_RS03915 (LP088_03905)	742656..743735	-	1080	WP_029103111.1	3-deoxy-7-phosphoheptulonate synthase	-
LP088_RS03920 (LP088_03910)	743942..744184	+	243	WP_078275235.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LP088_RS03925 (LP088_03915)	744184..744519	+	336	WP_078275234.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LP088_RS03930 (LP088_03920)	744581..745576	+	996	WP_208624081.1	polyprenyl synthetase family protein	-
LP088_RS03935 (LP088_03925)	745648..745836	+	189	WP_143821748.1	hypothetical protein	-
LP088_RS03940 (LP088_03930)	745926..748070	-	2145	WP_264676147.1	cation-translocating P-type ATPase	-
LP088_RS03945 (LP088_03935)	748235..748819	-	585	WP_112741954.1	hypothetical protein	-
LP088_RS03950 (LP088_03940)	748979..749179	-	201	WP_112741955.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (2-63)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13059.98 Da
• Isoelectric Point: 8.8194

>T226245 WP_078275234.1 NZ_CP087814:744184-744519 [Moraxella bovis]
MCELMYELEFDERALKEWQKLGDTIKTQFKKRLAKVLKNPHIIANRLSGGQNLYKINFRSAGYRLVYQVEDDKVVVFVIV
MGKREKNAVYDTAEEWLAERQSDNQDTQSVK

Nucleotide

• Length: 336 bp

>T226245 NZ_CP122319:4512644-4513018 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9034.47 Da
• Isoelectric Point: 4.7527

>AT226245 WP_078275235.1 NZ_CP087814:743942-744184 [Moraxella bovis]
MANIVARVDDDLKAQSFLVLQELGVTPSELIRQTLQYVAYHKKLPFKTVVLTDEDSELLALAKERLDNPAPRIKVSLDEL

Nucleotide

• Length: 243 bp

>AT226245 NZ_CP122319:4512187-4512555 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA