Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 639210..639859 Replicon chromosome
Accession NZ_CP087814
Organism Moraxella bovis strain SAM109238

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP088_RS03295 Protein ID WP_078274052.1
Coordinates 639458..639859 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP088_RS03290 Protein ID WP_112741908.1
Coordinates 639210..639443 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP088_RS03270 (LP088_03265) 634606..635055 - 450 WP_264676133.1 cytochrome c -
LP088_RS03275 (LP088_03270) 635237..636229 - 993 WP_078274055.1 oxygen-dependent coproporphyrinogen oxidase -
LP088_RS03280 (LP088_03275) 636249..636842 - 594 WP_208624078.1 GTP cyclohydrolase II -
LP088_RS03285 (LP088_03280) 637063..639162 + 2100 WP_078274054.1 1-deoxy-D-xylulose-5-phosphate synthase -
LP088_RS03290 (LP088_03285) 639210..639443 + 234 WP_112741908.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP088_RS03295 (LP088_03290) 639458..639859 + 402 WP_078274052.1 type II toxin-antitoxin system VapC family toxin Toxin
LP088_RS03300 (LP088_03295) 640383..640883 + 501 WP_112741909.1 WG repeat-containing protein -
LP088_RS03305 (LP088_03300) 641005..641835 + 831 WP_078274050.1 inositol monophosphatase family protein -
LP088_RS03310 (LP088_03305) 641934..642623 - 690 WP_078274049.1 SIMPL domain-containing protein -
LP088_RS03320 (LP088_03315) 643359..643778 - 420 WP_078274047.1 S4 domain-containing protein -
LP088_RS03325 (LP088_03320) 643775..643951 - 177 WP_228157829.1 ASCH domain-containing protein -
LP088_RS03330 (LP088_03325) 643970..644203 - 234 WP_112741910.1 ASCH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15131.33 Da        Isoelectric Point: 6.8510

>T226244 WP_078274052.1 NZ_CP087814:639458-639859 [Moraxella bovis]
MFSFMLDTNIYIYVIKERPIKALNKFNQYAGRICVSSIVASELYFGAYNSQFMDKNLHQVEDFLSRLTVLDYTAECSPHY
GEICADLTKQGKLISENDIHIASHARALGLTLITNNTDEFKRVSGLRIGNWAI

Download         Length: 402 bp

>T226244 NZ_CP122319:c4359058-4358955 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8990.22 Da        Isoelectric Point: 6.2884

>AT226244 WP_112741908.1 NZ_CP087814:639210-639443 [Moraxella bovis]
MQTSVFFNNRTQAVRIPAKFRFDDDVKAVMIRKVGNERILTPIDGVWDSFFLSDERASDDFMANRPTMPKSERLTFD

Download         Length: 234 bp

>AT226244 NZ_CP122319:4358917-4359188 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References