Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 478775..479433 Replicon chromosome
Accession NZ_CP087814
Organism Moraxella bovis strain SAM109238

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP088_RS02485 Protein ID WP_078274940.1
Coordinates 478775..478963 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP088_RS02490 Protein ID WP_112741846.1
Coordinates 479026..479433 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP088_RS02430 (LP088_02425) 474176..474595 - 420 WP_112741841.1 S24 family peptidase -
LP088_RS02435 (LP088_02430) 474592..474879 - 288 WP_078274962.1 ORF6C domain-containing protein -
LP088_RS02440 (LP088_02435) 475074..475373 - 300 WP_078274961.1 helix-turn-helix transcriptional regulator -
LP088_RS02445 (LP088_02440) 475538..475747 + 210 WP_078274960.1 hypothetical protein -
LP088_RS02450 (LP088_02445) 475762..475953 + 192 WP_264676101.1 DNA-binding protein -
LP088_RS02455 (LP088_02450) 475962..476162 + 201 WP_264676324.1 hypothetical protein -
LP088_RS02460 (LP088_02455) 476240..476992 + 753 WP_078274945.1 hypothetical protein -
LP088_RS02465 (LP088_02460) 477036..477380 - 345 WP_078274944.1 helix-turn-helix transcriptional regulator -
LP088_RS02470 (LP088_02465) 477503..477709 + 207 WP_264676102.1 DNA-binding protein -
LP088_RS02475 (LP088_02470) 477816..478415 + 600 WP_078274942.1 antA/AntB antirepressor family protein -
LP088_RS02480 (LP088_02475) 478417..478632 + 216 WP_078274941.1 hypothetical protein -
LP088_RS02485 (LP088_02480) 478775..478963 + 189 WP_078274940.1 type II toxin-antitoxin system HicA family toxin Toxin
LP088_RS02490 (LP088_02485) 479026..479433 + 408 WP_112741846.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP088_RS02495 (LP088_02490) 479509..480480 + 972 WP_112741847.1 phage tail tape measure protein -
LP088_RS02500 (LP088_02495) 480477..480809 + 333 WP_112741848.1 hypothetical protein -
LP088_RS02505 (LP088_02500) 480743..481180 + 438 WP_162860346.1 hypothetical protein -
LP088_RS02510 (LP088_02505) 481234..482040 + 807 WP_112741850.1 hypothetical protein -
LP088_RS02515 (LP088_02510) 482041..482385 + 345 WP_078274937.1 hypothetical protein -
LP088_RS02520 (LP088_02515) 482373..484202 + 1830 WP_078274936.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 474176..488670 14494


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-130)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7047.13 Da        Isoelectric Point: 10.3659

>T226243 WP_078274940.1 NZ_CP087814:478775-478963 [Moraxella bovis]
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD

Download         Length: 189 bp

>T226243 NZ_CP122319:c4081484-4081197 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14756.85 Da        Isoelectric Point: 4.2244

>AT226243 WP_112741846.1 NZ_CP087814:479026-479433 [Moraxella bovis]
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG

Download         Length: 408 bp

>AT226243 NZ_CP122319:c4081723-4081484 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References