Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2242675..2243333 Replicon chromosome
Accession NZ_CP087811
Organism Moraxella bovis strain SAM57928

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP106_RS11440 Protein ID WP_078274940.1
Coordinates 2243145..2243333 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP106_RS11435 Protein ID WP_112741846.1
Coordinates 2242675..2243082 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP106_RS11405 (LP106_11305) 2237906..2239735 - 1830 WP_078274936.1 hypothetical protein -
LP106_RS11410 (LP106_11310) 2239723..2240067 - 345 WP_078274937.1 hypothetical protein -
LP106_RS11415 (LP106_11315) 2240068..2240874 - 807 WP_112741850.1 hypothetical protein -
LP106_RS11420 (LP106_11320) 2240928..2241365 - 438 WP_162860346.1 hypothetical protein -
LP106_RS11425 (LP106_11325) 2241299..2241631 - 333 WP_112741848.1 hypothetical protein -
LP106_RS11430 (LP106_11330) 2241628..2242599 - 972 WP_112741847.1 phage tail tape measure protein -
LP106_RS11435 (LP106_11335) 2242675..2243082 - 408 WP_112741846.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP106_RS11440 (LP106_11340) 2243145..2243333 - 189 WP_078274940.1 type II toxin-antitoxin system HicA family toxin Toxin
LP106_RS11445 (LP106_11345) 2243476..2243691 - 216 WP_078274941.1 hypothetical protein -
LP106_RS11450 (LP106_11350) 2243693..2244292 - 600 WP_078274942.1 antA/AntB antirepressor family protein -
LP106_RS11455 (LP106_11355) 2244399..2244605 - 207 WP_264676102.1 DNA-binding protein -
LP106_RS11460 (LP106_11360) 2244728..2245072 + 345 WP_078274944.1 helix-turn-helix transcriptional regulator -
LP106_RS11465 (LP106_11365) 2245116..2245868 - 753 WP_078274945.1 hypothetical protein -
LP106_RS11470 (LP106_11370) 2245946..2246146 - 201 WP_264676324.1 hypothetical protein -
LP106_RS11475 (LP106_11375) 2246155..2246346 - 192 WP_264676101.1 DNA-binding protein -
LP106_RS11480 (LP106_11380) 2246361..2246570 - 210 WP_078274960.1 hypothetical protein -
LP106_RS11485 (LP106_11385) 2246735..2247034 + 300 WP_078274961.1 helix-turn-helix transcriptional regulator -
LP106_RS11490 (LP106_11390) 2247229..2247516 + 288 WP_078274962.1 ORF6C domain-containing protein -
LP106_RS11495 (LP106_11395) 2247513..2247932 + 420 WP_112741841.1 S24 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2233438..2247932 14494


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-130)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7047.13 Da        Isoelectric Point: 10.3659

>T226242 WP_078274940.1 NZ_CP087811:c2243333-2243145 [Moraxella bovis]
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD

Download         Length: 189 bp

>T226242 NZ_CP122319:c4028027-4026705 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14756.85 Da        Isoelectric Point: 4.2244

>AT226242 WP_112741846.1 NZ_CP087811:c2243082-2242675 [Moraxella bovis]
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG

Download         Length: 408 bp

>AT226242 NZ_CP122319:c4028293-4028027 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References