Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1418829..1419486 Replicon chromosome
Accession NZ_CP087811
Organism Moraxella bovis strain SAM57928

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP106_RS06930 Protein ID WP_264676287.1
Coordinates 1418829..1419011 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP106_RS06935 Protein ID WP_264676286.1
Coordinates 1419073..1419486 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP106_RS06905 (LP106_06840) 1414802..1416199 - 1398 WP_264676292.1 phage terminase large subunit -
LP106_RS06910 (LP106_06845) 1416199..1416738 - 540 WP_264676291.1 terminase small subunit -
LP106_RS06915 (LP106_06850) 1416852..1417061 + 210 WP_264676290.1 hypothetical protein -
LP106_RS06920 (LP106_06855) 1417098..1417298 + 201 WP_264676289.1 helix-turn-helix domain-containing protein -
LP106_RS06925 (LP106_06860) 1417725..1418429 - 705 WP_264676288.1 BRO family protein -
LP106_RS06930 (LP106_06865) 1418829..1419011 + 183 WP_264676287.1 type II toxin-antitoxin system HicA family toxin Toxin
LP106_RS06935 (LP106_06870) 1419073..1419486 + 414 WP_264676286.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP106_RS06940 (LP106_06875) 1419497..1419898 - 402 WP_264676285.1 antiterminator Q family protein -
LP106_RS06945 (LP106_06880) 1419882..1420103 - 222 WP_264676284.1 DUF3310 domain-containing protein -
LP106_RS06950 (LP106_06885) 1420100..1420255 - 156 WP_264676283.1 hypothetical protein -
LP106_RS06955 (LP106_06890) 1420392..1420877 - 486 WP_078273444.1 recombination protein NinB -
LP106_RS06960 (LP106_06895) 1420874..1421164 - 291 WP_112742084.1 hypothetical protein -
LP106_RS06965 (LP106_06900) 1421186..1421464 - 279 WP_264676282.1 hypothetical protein -
LP106_RS06970 (LP106_06905) 1421461..1421856 - 396 WP_264676281.1 VRR-NUC domain-containing protein -
LP106_RS06975 (LP106_06910) 1421853..1422461 - 609 WP_264676191.1 hypothetical protein -
LP106_RS06980 (LP106_06915) 1422454..1423344 - 891 WP_264676778.1 replication protein -
LP106_RS06985 (LP106_06920) 1423341..1424024 - 684 WP_264676189.1 Rha family transcriptional regulator -
LP106_RS06990 (LP106_06925) 1424092..1424367 - 276 WP_112742261.1 YdaS family helix-turn-helix protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1384645..1437935 53290


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-79)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6761.81 Da        Isoelectric Point: 10.7622

>T226236 WP_264676287.1 NZ_CP087811:1418829-1419011 [Moraxella bovis]
MKYSEFQRWLLAQGATVNKQGGKGSHRKVTLNGKTTTFPYHGSKEIGEGLRKKILKDLDL

Download         Length: 183 bp

>T226236 NZ_CP122319:c2917177-2916959 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15339.53 Da        Isoelectric Point: 4.7523

>AT226236 WP_264676286.1 NZ_CP087811:1419073-1419486 [Moraxella bovis]
MYYPATFTPDTNDTFLVAFRDIPEAVGVGETFEIAYQSALDGLETAFSIYMDERKPIPAPSELSDGEHAIYLPVAVQTKL
ALYHEMLAQGVTKAELARRLSVNQKQIDRLWDVSHSTKLEFLEKAFSVLGKRLSLAI

Download         Length: 414 bp

>AT226236 NZ_CP122319:c2917577-2917203 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References