Detailed information of TA system TA226234

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 438002..438654
• Replicon: chromosome
• Accession: NZ_CP087811
• Organism: Moraxella bovis strain SAM57928

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LP106_RS02215
• Protein ID: WP_078275188.1
• Coordinates: 438262..438654 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LP106_RS02210
• Protein ID: WP_264675982.1
• Coordinates: 438002..438265 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP106_RS02180 (LP106_02170)	433287..434621	+	1335	WP_112741795.1	deoxyguanosinetriphosphate triphosphohydrolase	-
LP106_RS02185 (LP106_02175)	434765..435058	+	294	WP_029103533.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
LP106_RS02190 (LP106_02180)	435051..435323	+	273	WP_228157760.1	type II toxin-antitoxin system YafQ family toxin	-
LP106_RS02195 (LP106_02185)	435388..435843	-	456	WP_264675985.1	type IV secretion protein Rhs	-
LP106_RS02200 (LP106_02190)	435928..436305	+	378	WP_264675984.1	hypothetical protein	-
LP106_RS02205 (LP106_02195)	436663..437922	+	1260	WP_264675983.1	replication-associated recombination protein A	-
LP106_RS02210 (LP106_02200)	438002..438265	+	264	WP_264675982.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
LP106_RS02215 (LP106_02205)	438262..438654	+	393	WP_078275188.1	type II toxin-antitoxin system VapC family toxin	Toxin
LP106_RS02220 (LP106_02210)	438777..439307	+	531	WP_078275187.1	HI_0552 family protein	-
LP106_RS02225 (LP106_02215)	439304..439870	-	567	WP_078275186.1	hypothetical protein	-
LP106_RS02230 (LP106_02220)	439873..440109	-	237	WP_078275185.1	sulfurtransferase TusA	-
LP106_RS02235 (LP106_02225)	440106..440564	-	459	WP_078275184.1	acyl-CoA thioesterase	-
LP106_RS02240 (LP106_02230)	440644..441666	-	1023	WP_078275183.1	hypothetical protein	-
LP106_RS02245 (LP106_02235)	441697..442575	-	879	WP_112741796.1	uroporphyrinogen-III synthase	-
LP106_RS02250 (LP106_02240)	442621..443562	-	942	WP_078275181.1	hydroxymethylbilane synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-122)

Antitoxin

• SpoVT-AbrB domain (10-50)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14689.79 Da
• Isoelectric Point: 4.7370

>T226234 WP_078275188.1 NZ_CP087811:438262-438654 [Moraxella bovis]
MKYLLDTNAVIAILNASERFLTTLERHKEREIAISSIVLSELYYGAYKSQKTAQNLEKINLLPFEVLQFNSQDADKAGEI
GATLERRGTPIGFYDTLIAGQAIANDLIVITDNVREFLRVDGLQIENWLK

Nucleotide

• Length: 393 bp

>T226234 NZ_CP122319:2689835-2690233 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10153.49 Da
• Isoelectric Point: 6.3724

>AT226234 WP_264675982.1 NZ_CP087811:438002-438265 [Moraxella bovis]
MRQTATAKLFWTGNSQAVRLPKAFRFEGTEVRIKKQGRQVIIEPAETQDWAWLDKLRAMPKDDSFEEAILEGRQNLKADE
RDWGAFE

Nucleotide

• Length: 264 bp

>AT226234 NZ_CP122319:2689539-2689832 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA