Detailed information of TA system TA226233

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 434765..435323
• Replicon: chromosome
• Accession: NZ_CP087811
• Organism: Moraxella bovis strain SAM57928

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LP106_RS02190
• Protein ID: WP_228157760.1
• Coordinates: 435051..435323 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1S9ZVK6
• Locus tag: LP106_RS02185
• Protein ID: WP_029103533.1
• Coordinates: 434765..435058 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP106_RS02165 (LP106_02155)	430276..431610	-	1335	WP_078275195.1	valine--pyruvate transaminase	-
LP106_RS02170 (LP106_02160)	431730..432341	+	612	WP_112741794.1	methyltransferase	-
LP106_RS02175 (LP106_02165)	432362..433078	+	717	WP_078275193.1	hypothetical protein	-
LP106_RS02180 (LP106_02170)	433287..434621	+	1335	WP_112741795.1	deoxyguanosinetriphosphate triphosphohydrolase	-
LP106_RS02185 (LP106_02175)	434765..435058	+	294	WP_029103533.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LP106_RS02190 (LP106_02180)	435051..435323	+	273	WP_228157760.1	type II toxin-antitoxin system YafQ family toxin	Toxin
LP106_RS02195 (LP106_02185)	435388..435843	-	456	WP_264675985.1	type IV secretion protein Rhs	-
LP106_RS02200 (LP106_02190)	435928..436305	+	378	WP_264675984.1	hypothetical protein	-
LP106_RS02205 (LP106_02195)	436663..437922	+	1260	WP_264675983.1	replication-associated recombination protein A	-
LP106_RS02210 (LP106_02200)	438002..438265	+	264	WP_264675982.1	type II toxin-antitoxin system VapB family antitoxin	-
LP106_RS02215 (LP106_02205)	438262..438654	+	393	WP_078275188.1	type II toxin-antitoxin system VapC family toxin	-
LP106_RS02220 (LP106_02210)	438777..439307	+	531	WP_078275187.1	HI_0552 family protein	-
LP106_RS02225 (LP106_02215)	439304..439870	-	567	WP_078275186.1	hypothetical protein	-
LP106_RS02230 (LP106_02220)	439873..440109	-	237	WP_078275185.1	sulfurtransferase TusA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (6-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-67)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10415.99 Da
• Isoelectric Point: 6.9668

>T226233 WP_228157760.1 NZ_CP087811:435051-435323 [Moraxella bovis]
VAKRSFEMGNPFKRDLKKHYLALIGEAWTEVSDCLLNAKPIPQKYQDHPLQGDWVGFRDCHIKPDLVLIYKINDEAVELH
RLATHSELFG

Nucleotide

• Length: 273 bp

>T226233 NZ_CP122319:c2683773-2683495 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11068.31 Da
• Isoelectric Point: 4.7769

>AT226233 WP_029103533.1 NZ_CP087811:434765-435058 [Moraxella bovis]
MSHTNFNMRLDNDLRQKAYPVLEQYGLTPSQAVRMFFNQIAQTGKVPLSFDWGQSHTLSSNGEKLLRESIQAFENGETER
FDSLDELNQAMAEIARG

Nucleotide

• Length: 294 bp

>AT226233 NZ_CP122319:c2684036-2683776 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1S9ZVK6