Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2186900..2187552 Replicon chromosome
Accession NZ_CP087806
Organism Moraxella bovis strain SAM57939

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP117_RS11125 Protein ID WP_264677325.1
Coordinates 2187160..2187552 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP117_RS11120 Protein ID WP_264675982.1
Coordinates 2186900..2187163 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP117_RS11075 (LP117_10985) 2181998..2182201 + 204 WP_115368689.1 hypothetical protein -
LP117_RS11080 (LP117_10990) 2182321..2183394 + 1074 WP_264688800.1 dNTP triphosphohydrolase -
LP117_RS11085 (LP117_10995) 2183421..2183636 + 216 WP_264688801.1 hypothetical protein -
LP117_RS11090 (LP117_11000) 2183780..2184073 + 294 WP_264688802.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
LP117_RS11095 (LP117_11005) 2184066..2184338 + 273 WP_228157760.1 type II toxin-antitoxin system YafQ family toxin -
LP117_RS11100 (LP117_11010) 2184403..2184858 - 456 WP_264675985.1 type IV secretion protein Rhs -
LP117_RS11105 (LP117_11015) 2184918..2185187 + 270 WP_264677328.1 hypothetical protein -
LP117_RS11110 (LP117_11020) 2185184..2185564 + 381 WP_264688803.1 type II toxin-antitoxin system VapC family toxin -
LP117_RS11115 (LP117_11025) 2185561..2186820 + 1260 WP_264688804.1 replication-associated recombination protein A -
LP117_RS11120 (LP117_11030) 2186900..2187163 + 264 WP_264675982.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP117_RS11125 (LP117_11035) 2187160..2187552 + 393 WP_264677325.1 type II toxin-antitoxin system VapC family toxin Toxin
LP117_RS11130 (LP117_11040) 2187675..2188205 + 531 WP_078275187.1 HI_0552 family protein -
LP117_RS11135 (LP117_11045) 2188202..2188768 - 567 WP_078275186.1 hypothetical protein -
LP117_RS11140 (LP117_11050) 2188771..2189007 - 237 WP_078275185.1 sulfurtransferase TusA -
LP117_RS11145 (LP117_11055) 2189004..2189462 - 459 WP_078275184.1 acyl-CoA thioesterase -
LP117_RS11150 (LP117_11060) 2189542..2190564 - 1023 WP_078275183.1 hypothetical protein -
LP117_RS11155 (LP117_11065) 2190595..2191473 - 879 WP_112741796.1 uroporphyrinogen-III synthase -
LP117_RS11160 (LP117_11070) 2191519..2192460 - 942 WP_078275181.1 hydroxymethylbilane synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-122)

Antitoxin

SpoVT-AbrB domain

(10-50)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14629.69 Da        Isoelectric Point: 4.7370

>T226231 WP_264677325.1 NZ_CP087806:2187160-2187552 [Moraxella bovis]
MKYLLDTNAVIAILNASERFLTTLERHKEREIAISSIVLSELYYGAYKSQKTAQNLEKINLLPFEVLQFNSQDADKAGEI
GATLERRGTPIGSYDTLIAGQAIANDLIVITDNVREFLRVDGLQIENWLK

Download         Length: 393 bp

>T226231 NZ_CP122319:c2333448-2333191 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10153.49 Da        Isoelectric Point: 6.3724

>AT226231 WP_264675982.1 NZ_CP087806:2186900-2187163 [Moraxella bovis]
MRQTATAKLFWTGNSQAVRLPKAFRFEGTEVRIKKQGRQVIIEPAETQDWAWLDKLRAMPKDDSFEEAILEGRQNLKADE
RDWGAFE

Download         Length: 264 bp

>AT226231 NZ_CP122319:c2333179-2332634 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References