Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1742541..1743170 Replicon chromosome
Accession NZ_CP087806
Organism Moraxella bovis strain SAM57939

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP117_RS08770 Protein ID WP_264688770.1
Coordinates 1742979..1743170 (-) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP117_RS08765 Protein ID WP_264688769.1
Coordinates 1742541..1742945 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP117_RS08755 (LP117_08690) 1738176..1738571 - 396 WP_264676533.1 hypothetical protein -
LP117_RS08760 (LP117_08695) 1738650..1742465 - 3816 WP_264676534.1 phage tail tape measure protein -
LP117_RS08765 (LP117_08700) 1742541..1742945 - 405 WP_264688769.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP117_RS08770 (LP117_08705) 1742979..1743170 - 192 WP_264688770.1 type II toxin-antitoxin system HicA family toxin Toxin
LP117_RS08775 (LP117_08710) 1743318..1743506 - 189 WP_115008210.1 hypothetical protein -
LP117_RS08780 (LP117_08715) 1743509..1744225 - 717 WP_264688771.1 antA/AntB antirepressor family protein -
LP117_RS08785 (LP117_08720) 1744222..1744608 - 387 WP_115008209.1 hypothetical protein -
LP117_RS08790 (LP117_08725) 1744725..1745204 + 480 WP_264688772.1 helix-turn-helix domain containing protein -
LP117_RS08795 (LP117_08730) 1745276..1746025 - 750 WP_264688773.1 hypothetical protein -
LP117_RS08800 (LP117_08735) 1746094..1746423 - 330 WP_264688774.1 Gp49 family protein -
LP117_RS08805 (LP117_08740) 1746488..1747480 - 993 WP_078274947.1 major capsid protein -
LP117_RS08810 (LP117_08745) 1747525..1747899 - 375 WP_078274948.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1728781..1781514 52733


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7027.10 Da        Isoelectric Point: 11.0174

>T226228 WP_264688770.1 NZ_CP087806:c1743170-1742979 [Moraxella bovis]
MASSREVIKIIKADGWYRVKSNGGSHQQFKHPTKKGRVTVPHPKKDLAQPTIDSIMRQAGLSD

Download         Length: 192 bp

>T226228 NZ_CP122319:c1503024-1502917 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 15038.16 Da        Isoelectric Point: 4.7053

>AT226228 WP_264688769.1 NZ_CP087806:c1742945-1742541 [Moraxella bovis]
MLYPIAILKGDDKTAHGIFFPDVPNLASACDDLQDVHKMALECLDVHFSGLVEDGEEIPLPTNFDAHTQNSQFDGMMWAW
VDVDLSKYDVKSHKINITLPNYLIAKIDEKVLSHKSLYKSRSNYLAQLAMADLG

Download         Length: 405 bp

>AT226228 NZ_CP122319:1503073-1503139 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References