Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1601890..1602466 Replicon chromosome
Accession NZ_CP087806
Organism Moraxella bovis strain SAM57939

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP117_RS08085 Protein ID WP_228157854.1
Coordinates 1601890..1602150 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP117_RS08090 Protein ID WP_078273964.1
Coordinates 1602131..1602466 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP117_RS08070 (LP117_08015) 1596921..1598996 + 2076 WP_112742539.1 NAD-dependent DNA ligase LigA -
LP117_RS08075 (LP117_08020) 1599509..1600894 + 1386 WP_078273966.1 APC family permease -
LP117_RS08080 (LP117_08025) 1600984..1601691 - 708 WP_078273965.1 ParA family protein -
LP117_RS08085 (LP117_08030) 1601890..1602150 + 261 WP_228157854.1 type II toxin-antitoxin system HicA family toxin Toxin
LP117_RS08090 (LP117_08035) 1602131..1602466 + 336 WP_078273964.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP117_RS08095 (LP117_08040) 1602650..1603234 - 585 Protein_1583 TetR/AcrR family transcriptional regulator -
LP117_RS08100 (LP117_08045) 1603497..1604678 + 1182 WP_078274027.1 fatty acid desaturase -
LP117_RS08105 (LP117_08050) 1605324..1606091 + 768 WP_112742541.1 carbonic anhydrase family protein -
LP117_RS08110 (LP117_08055) 1606225..1607307 + 1083 WP_078273961.1 tRNA pseudouridine(13) synthase TruD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9574.50 Da        Isoelectric Point: 4.4681

>T226227 WP_228157854.1 NZ_CP087806:1601890-1602150 [Moraxella bovis]
IEALFVALGADISERAGSRMAVALNGQVMVFHRPHPSPNTDKSAVMSIRKWLDGMGITPLDDDSQTDEYADKQTDEQEQT
HEHHDN

Download         Length: 261 bp

>T226227 NZ_CP122319:1080273-1080737 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12189.67 Da        Isoelectric Point: 4.5658

>AT226227 WP_078273964.1 NZ_CP087806:1602131-1602466 [Moraxella bovis]
MNTMTINNHKALITFDSELGLFRGEFIGLNGGADFYADSVDGLNEQGALSLQAFLDVCQEQGISPYQSYSGKFVTRLPKE
LHQKIAETATAKGISLNQWINETLSREVGFA

Download         Length: 336 bp

>AT226227 NZ_CP122319:1079938-1080273 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References