Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 842947..843604 Replicon chromosome
Accession NZ_CP087806
Organism Moraxella bovis strain SAM57939

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP117_RS04515 Protein ID WP_264676287.1
Coordinates 843422..843604 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP117_RS04510 Protein ID WP_264676286.1
Coordinates 842947..843360 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP117_RS04465 (LP117_04435) 838595..839230 + 636 WP_264688921.1 hypothetical protein -
LP117_RS04470 (LP117_04440) 839227..839634 + 408 WP_112742083.1 VRR-NUC domain-containing protein -
LP117_RS04475 (LP117_04445) 839631..839909 + 279 WP_264682994.1 hypothetical protein -
LP117_RS04480 (LP117_04450) 839956..840153 - 198 WP_264682993.1 ribbon-helix-helix domain-containing protein -
LP117_RS04485 (LP117_04455) 840815..841492 + 678 WP_264682991.1 Bro-N domain-containing protein -
LP117_RS04490 (LP117_04460) 841556..842041 + 486 WP_264688965.1 recombination protein NinB -
LP117_RS04495 (LP117_04465) 842178..842333 + 156 WP_264676283.1 hypothetical protein -
LP117_RS04500 (LP117_04470) 842330..842551 + 222 WP_264676284.1 DUF3310 domain-containing protein -
LP117_RS04505 (LP117_04475) 842535..842936 + 402 WP_264676285.1 antiterminator Q family protein -
LP117_RS04510 (LP117_04480) 842947..843360 - 414 WP_264676286.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP117_RS04515 (LP117_04485) 843422..843604 - 183 WP_264676287.1 type II toxin-antitoxin system HicA family toxin Toxin
LP117_RS04520 (LP117_04490) 844004..844708 + 705 WP_264676288.1 BRO family protein -
LP117_RS04525 (LP117_04495) 845135..845335 - 201 WP_264676289.1 helix-turn-helix domain-containing protein -
LP117_RS04530 (LP117_04500) 845372..845581 - 210 WP_264676290.1 hypothetical protein -
LP117_RS04535 (LP117_04505) 845695..846234 + 540 WP_264676291.1 terminase small subunit -
LP117_RS04540 (LP117_04510) 846234..847631 + 1398 WP_264676292.1 phage terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 823111..875083 51972


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-79)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6761.81 Da        Isoelectric Point: 10.7622

>T226226 WP_264676287.1 NZ_CP087806:c843604-843422 [Moraxella bovis]
MKYSEFQRWLLAQGATVNKQGGKGSHRKVTLNGKTTTFPYHGSKEIGEGLRKKILKDLDL

Download         Length: 183 bp

>T226226 NZ_CP122319:c1037391-1037077 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15339.53 Da        Isoelectric Point: 4.7523

>AT226226 WP_264676286.1 NZ_CP087806:c843360-842947 [Moraxella bovis]
MYYPATFTPDTNDTFLVAFRDIPEAVGVGETFEIAYQSALDGLETAFSIYMDERKPIPAPSELSDGEHAIYLPVAVQTKL
ALYHEMLAQGVTKAELARRLSVNQKQIDRLWDVSHSTKLEFLEKAFSVLGKRLSLAI

Download         Length: 414 bp

>AT226226 NZ_CP122319:c1037080-1036664 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References