Detailed information of TA system TA226224

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): AbkB-shpB/BrnT-BrnA
• Location: 521012..521564
• Replicon: chromosome
• Accession: NZ_CP087806
• Organism: Moraxella bovis strain SAM57939

Toxin (Protein)

• Gene name: AbkB
• Uniprot ID: A0A1T0A7D3
• Locus tag: LP117_RS02805
• Protein ID: WP_029102268.1
• Coordinates: 521286..521564 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: -
• Locus tag: LP117_RS02800
• Protein ID: WP_078273473.1
• Coordinates: 521012..521299 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP117_RS02785 (LP117_02780)	516426..517475	+	1050	WP_264688935.1	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	-
LP117_RS02790 (LP117_02785)	517554..519074	+	1521	WP_264688936.1	DUF389 domain-containing protein	-
LP117_RS02795 (LP117_02790)	519272..521002	-	1731	WP_078273474.1	flotillin domain-containing protein	-
LP117_RS02800 (LP117_02795)	521012..521299	-	288	WP_078273473.1	BrnA antitoxin family protein	Antitoxin
LP117_RS02805 (LP117_02800)	521286..521564	-	279	WP_029102268.1	BrnT family toxin	Toxin
LP117_RS02810 (LP117_02805)	521646..522302	-	657	WP_264688937.1	YqiJ family protein	-
LP117_RS02815 (LP117_02810)	522502..523167	-	666	WP_115369658.1	PspA/IM30 family protein	-
LP117_RS02820 (LP117_02815)	523380..523562	-	183	WP_264683628.1	hypothetical protein	-
LP117_RS02825 (LP117_02820)	523663..524178	-	516	WP_078273469.1	hypothetical protein	-
LP117_RS02830 (LP117_02825)	524326..524676	-	351	WP_115369661.1	TIGR01244 family sulfur transferase	-
LP117_RS02835 (LP117_02830)	524789..525564	+	776	Protein_550	nucleotidyltransferase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-85)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (36-89)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10484.81 Da
• Isoelectric Point: 5.1084

>T226224 WP_029102268.1 NZ_CP087806:c521564-521286 [Moraxella bovis]
MIFEWDDNKNRTNKQKHGVSFESASRIFLDPFLIVTEDTSSDEVRWLGVGSVDGVVILLVVHTHTDTDGTEIIRIISARK
LSRGEIERYGYC

Nucleotide

• Length: 279 bp

>T226224 NZ_CP122319:c843759-843352 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10979.71 Da
• Isoelectric Point: 7.0097

>AT226224 WP_078273473.1 NZ_CP087806:c521299-521012 [Moraxella bovis]
MAIVRKTLDDIKHTPIDKDELAQLQSMSDDSINYDDIPPLTDVQIANLRLYKPIKQQITLRLDSDIVAWLKKDGKGYQTR
ANQLLRQLMLKELTT

Nucleotide

• Length: 288 bp

>AT226224 NZ_CP122319:c844006-843740 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A1T0A7D3