Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 35799..36457 | Replicon | chromosome |
| Accession | NZ_CP087806 | ||
| Organism | Moraxella bovis strain SAM57939 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | LP117_RS00200 | Protein ID | WP_078274940.1 |
| Coordinates | 35799..35987 (+) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | LP117_RS00205 | Protein ID | WP_112741846.1 |
| Coordinates | 36050..36457 (+) | Length | 136 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LP117_RS00145 (LP117_00140) | 31200..31619 | - | 420 | WP_112741841.1 | S24 family peptidase | - |
| LP117_RS00150 (LP117_00145) | 31616..31903 | - | 288 | WP_078274962.1 | ORF6C domain-containing protein | - |
| LP117_RS00155 (LP117_00150) | 32098..32397 | - | 300 | WP_078274961.1 | helix-turn-helix transcriptional regulator | - |
| LP117_RS00160 (LP117_00155) | 32562..32771 | + | 210 | WP_264688815.1 | DNA-binding protein | - |
| LP117_RS00165 (LP117_00160) | 32786..32977 | + | 192 | WP_264676101.1 | DNA-binding protein | - |
| LP117_RS00170 (LP117_00165) | 32986..33186 | + | 201 | WP_264676324.1 | hypothetical protein | - |
| LP117_RS00175 (LP117_00170) | 33264..34016 | + | 753 | WP_078274945.1 | hypothetical protein | - |
| LP117_RS00180 (LP117_00175) | 34060..34404 | - | 345 | WP_264688874.1 | helix-turn-helix transcriptional regulator | - |
| LP117_RS00185 (LP117_00180) | 34527..34733 | + | 207 | WP_264676102.1 | DNA-binding protein | - |
| LP117_RS00190 (LP117_00185) | 34840..35439 | + | 600 | WP_078274942.1 | antA/AntB antirepressor family protein | - |
| LP117_RS00195 (LP117_00190) | 35441..35656 | + | 216 | WP_078274941.1 | hypothetical protein | - |
| LP117_RS00200 (LP117_00195) | 35799..35987 | + | 189 | WP_078274940.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| LP117_RS00205 (LP117_00200) | 36050..36457 | + | 408 | WP_112741846.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| LP117_RS00210 (LP117_00205) | 36533..37504 | + | 972 | WP_112741847.1 | phage tail tape measure protein | - |
| LP117_RS00215 (LP117_00210) | 37501..37833 | + | 333 | WP_112741848.1 | hypothetical protein | - |
| LP117_RS00220 (LP117_00215) | 37767..38204 | + | 438 | WP_162860346.1 | hypothetical protein | - |
| LP117_RS00225 (LP117_00220) | 38258..39064 | + | 807 | WP_264684230.1 | hypothetical protein | - |
| LP117_RS00230 (LP117_00225) | 39065..39409 | + | 345 | WP_078274937.1 | hypothetical protein | - |
| LP117_RS00235 (LP117_00230) | 39397..41226 | + | 1830 | WP_078274936.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 31200..45694 | 14494 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7047.13 Da Isoelectric Point: 10.3659
>T226220 WP_078274940.1 NZ_CP087806:35799-35987 [Moraxella bovis]
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD
Download Length: 189 bp
>T226220 NZ_CP122318:4479267-4479674 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 136 a.a. Molecular weight: 14756.85 Da Isoelectric Point: 4.2244
>AT226220 WP_112741846.1 NZ_CP087806:36050-36457 [Moraxella bovis]
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG
Download Length: 408 bp
>AT226220 NZ_CP122318:4479020-4479286 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|