Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2236731..2237383 Replicon chromosome
Accession NZ_CP087805
Organism Moraxella bovis strain SAM57942

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP119_RS11285 Protein ID WP_264677325.1
Coordinates 2236731..2237123 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP119_RS11290 Protein ID WP_264675982.1
Coordinates 2237120..2237383 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP119_RS11250 (LP119_11190) 2231824..2232765 + 942 WP_078275181.1 hydroxymethylbilane synthase -
LP119_RS11255 (LP119_11195) 2232811..2233689 + 879 WP_264677322.1 uroporphyrinogen-III synthase -
LP119_RS11260 (LP119_11200) 2233720..2234742 + 1023 WP_264677323.1 hypothetical protein -
LP119_RS11265 (LP119_11205) 2234821..2235279 + 459 WP_264677324.1 acyl-CoA thioesterase -
LP119_RS11270 (LP119_11210) 2235276..2235512 + 237 WP_078275185.1 sulfurtransferase TusA -
LP119_RS11275 (LP119_11215) 2235515..2236081 + 567 WP_078275186.1 hypothetical protein -
LP119_RS11280 (LP119_11220) 2236078..2236608 - 531 WP_264678418.1 glucose-6-phosphate 1-dehydrogenase family protein -
LP119_RS11285 (LP119_11225) 2236731..2237123 - 393 WP_264677325.1 type II toxin-antitoxin system VapC family toxin Toxin
LP119_RS11290 (LP119_11230) 2237120..2237383 - 264 WP_264675982.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP119_RS11295 (LP119_11235) 2237463..2238722 - 1260 WP_264677326.1 replication-associated recombination protein A -
LP119_RS11300 (LP119_11240) 2238719..2239099 - 381 WP_264677327.1 type II toxin-antitoxin system VapC family toxin -
LP119_RS11305 (LP119_11245) 2239096..2239365 - 270 WP_264677328.1 hypothetical protein -
LP119_RS11310 (LP119_11250) 2239425..2239880 + 456 WP_264677329.1 type IV secretion protein Rhs -
LP119_RS11315 (LP119_11255) 2239945..2240217 - 273 WP_228157760.1 type II toxin-antitoxin system YafQ family toxin -
LP119_RS11320 (LP119_11260) 2240210..2240503 - 294 WP_264677330.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
LP119_RS11325 (LP119_11265) 2240647..2241981 - 1335 WP_264677331.1 deoxyguanosinetriphosphate triphosphohydrolase -
LP119_RS11330 (LP119_11270) 2242101..2242304 - 204 WP_115368689.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-122)

Antitoxin

SpoVT-AbrB domain

(10-50)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14629.69 Da        Isoelectric Point: 4.7370

>T226218 WP_264677325.1 NZ_CP087805:c2237123-2236731 [Moraxella bovis]
MKYLLDTNAVIAILNASERFLTTLERHKEREIAISSIVLSELYYGAYKSQKTAQNLEKINLLPFEVLQFNSQDADKAGEI
GATLERRGTPIGSYDTLIAGQAIANDLIVITDNVREFLRVDGLQIENWLK

Download         Length: 393 bp

>T226218 NZ_CP122318:4310754-4311068 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10153.49 Da        Isoelectric Point: 6.3724

>AT226218 WP_264675982.1 NZ_CP087805:c2237383-2237120 [Moraxella bovis]
MRQTATAKLFWTGNSQAVRLPKAFRFEGTEVRIKKQGRQVIIEPAETQDWAWLDKLRAMPKDDSFEEAILEGRQNLKADE
RDWGAFE

Download         Length: 264 bp

>AT226218 NZ_CP122318:4311065-4311481 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References