Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1958730..1959306 Replicon chromosome
Accession NZ_CP087805
Organism Moraxella bovis strain SAM57942

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP119_RS09880 Protein ID WP_264676341.1
Coordinates 1958730..1958990 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP119_RS09885 Protein ID WP_078273964.1
Coordinates 1958971..1959306 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP119_RS09865 (LP119_09800) 1953761..1955836 + 2076 WP_264677152.1 NAD-dependent DNA ligase LigA -
LP119_RS09870 (LP119_09805) 1956348..1957733 + 1386 WP_078273966.1 APC family permease -
LP119_RS09875 (LP119_09810) 1957823..1958531 - 709 Protein_1940 ParA family protein -
LP119_RS09880 (LP119_09815) 1958730..1958990 + 261 WP_264676341.1 type II toxin-antitoxin system HicA family toxin Toxin
LP119_RS09885 (LP119_09820) 1958971..1959306 + 336 WP_078273964.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP119_RS09890 (LP119_09825) 1959490..1960074 - 585 Protein_1943 TetR/AcrR family transcriptional regulator -
LP119_RS09895 (LP119_09830) 1960337..1961518 + 1182 WP_264678410.1 fatty acid desaturase -
LP119_RS09900 (LP119_09835) 1962165..1962515 + 351 WP_264677153.1 hypothetical protein -
LP119_RS09905 (LP119_09840) 1962527..1962961 + 435 WP_264677154.1 carbonic anhydrase family protein -
LP119_RS09910 (LP119_09845) 1963065..1964147 + 1083 WP_264677155.1 tRNA pseudouridine(13) synthase TruD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9551.46 Da        Isoelectric Point: 4.3376

>T226217 WP_264676341.1 NZ_CP087805:1958730-1958990 [Moraxella bovis]
IEALFVALGADISERAGSRMAVALNGQVMVFHRPHPSPNTDKSAVMSIRKWLDGMGITPLDDDSQTDEYADKQTDEQEQT
HEHNDN

Download         Length: 261 bp

>T226217 NZ_CP122318:c4267872-4267408 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12189.67 Da        Isoelectric Point: 4.5658

>AT226217 WP_078273964.1 NZ_CP087805:1958971-1959306 [Moraxella bovis]
MNTMTINNHKALITFDSELGLFRGEFIGLNGGADFYADSVDGLNEQGALSLQAFLDVCQEQGISPYQSYSGKFVTRLPKE
LHQKIAETATAKGISLNQWINETLSREVGFA

Download         Length: 336 bp

>AT226217 NZ_CP122318:c4268207-4267872 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References