Detailed information of TA system TA226215

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): AbkB-shpB/BrnT-BrnA
• Location: 949804..950356
• Replicon: chromosome
• Accession: NZ_CP087805
• Organism: Moraxella bovis strain SAM57942

Toxin (Protein)

• Gene name: AbkB
• Uniprot ID: A0A1T0A7D3
• Locus tag: LP119_RS04840
• Protein ID: WP_029102268.1
• Coordinates: 950078..950356 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: -
• Locus tag: LP119_RS04835
• Protein ID: WP_078273473.1
• Coordinates: 949804..950091 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LP119_RS04815 (LP119_04795)	945218..946267	+	1050	WP_264678112.1	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	-
LP119_RS04820 (LP119_04800)	946346..947866	+	1521	WP_264678113.1	DUF389 domain-containing protein	-
LP119_RS04825	947895..948020	+	126	WP_264676709.1	hypothetical protein	-
LP119_RS04830 (LP119_04805)	948064..949794	-	1731	WP_078273474.1	flotillin domain-containing protein	-
LP119_RS04835 (LP119_04810)	949804..950091	-	288	WP_078273473.1	BrnA antitoxin family protein	Antitoxin
LP119_RS04840 (LP119_04815)	950078..950356	-	279	WP_029102268.1	BrnT family toxin	Toxin
LP119_RS04845 (LP119_04820)	950451..951107	-	657	WP_264678114.1	YqiJ family protein	-
LP119_RS04850 (LP119_04825)	951307..951972	-	666	WP_264678115.1	PspA/IM30 family protein	-
LP119_RS04855 (LP119_04830)	952185..952367	-	183	WP_264683628.1	hypothetical protein	-
LP119_RS04860 (LP119_04835)	952468..952983	-	516	WP_264678117.1	hypothetical protein	-
LP119_RS04865 (LP119_04840)	953131..953481	-	351	WP_078273468.1	TIGR01244 family sulfur transferase	-
LP119_RS04870 (LP119_04845)	953594..954370	+	777	WP_264678118.1	nucleotidyltransferase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-85)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (36-89)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10484.81 Da
• Isoelectric Point: 5.1084

>T226215 WP_029102268.1 NZ_CP087805:c950356-950078 [Moraxella bovis]
MIFEWDDNKNRTNKQKHGVSFESASRIFLDPFLIVTEDTSSDEVRWLGVGSVDGVVILLVVHTHTDTDGTEIIRIISARK
LSRGEIERYGYC

Nucleotide

• Length: 279 bp

>T226215 NZ_CP122318:c2941659-2941318 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10979.71 Da
• Isoelectric Point: 7.0097

>AT226215 WP_078273473.1 NZ_CP087805:c950091-949804 [Moraxella bovis]
MAIVRKTLDDIKHTPIDKDELAQLQSMSDDSINYDDIPPLTDVQIANLRLYKPIKQQITLRLDSDIVAWLKKDGKGYQTR
ANQLLRQLMLKELTT

Nucleotide

• Length: 288 bp

>AT226215 NZ_CP122318:2941654-2941730 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A1T0A7D3