Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 204798..205422 Replicon chromosome
Accession NZ_CP087805
Organism Moraxella bovis strain SAM57942

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP119_RS01090 Protein ID WP_264677651.1
Coordinates 204798..205100 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP119_RS01095 Protein ID WP_264677652.1
Coordinates 205087..205422 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP119_RS01065 (LP119_01060) 199892..200446 + 555 WP_078274416.1 porin family protein -
LP119_RS01070 (LP119_01065) 200703..202058 - 1356 WP_272506296.1 FAD-dependent oxidoreductase -
LP119_RS01080 (LP119_01075) 202077..203195 - 1119 WP_264677649.1 acyl-CoA dehydrogenase family protein -
LP119_RS01085 (LP119_01080) 203305..204660 - 1356 WP_264677650.1 anthranilate synthase component I family protein -
LP119_RS01090 (LP119_01085) 204798..205100 + 303 WP_264677651.1 type II toxin-antitoxin system HicA family toxin Toxin
LP119_RS01095 (LP119_01090) 205087..205422 + 336 WP_264677652.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP119_RS01100 (LP119_01095) 205455..205919 - 465 WP_264677653.1 hypothetical protein -
LP119_RS01105 (LP119_01100) 206107..207339 - 1233 WP_264677654.1 beta-ketoacyl-ACP synthase II -
LP119_RS01110 (LP119_01105) 207514..208254 - 741 WP_112742704.1 single-stranded DNA-binding protein -
LP119_RS01115 (LP119_01110) 208714..209031 - 318 WP_078274423.1 H-NS histone family protein -
LP119_RS01120 (LP119_01115) 209240..210310 - 1071 WP_115368772.1 5'-nucleotidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(21-73)

Antitoxin

Uncharacterised protein family HicB

(52-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11427.89 Da        Isoelectric Point: 6.3267

>T226212 WP_264677651.1 NZ_CP087805:204798-205100 [Moraxella bovis]
MTKSDKLKAKLYGDVRTFVFSDLVTLLSQLGYEMHERAGSRVVFVHCDDNSDRIHLHKPHPENTIKGGALKAVKAYLSEK
GYFDEFNDDVLNQELKNDDL

Download         Length: 303 bp

>T226212 NZ_CP122318:c2482378-2482160 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12590.10 Da        Isoelectric Point: 4.4118

>AT226212 WP_264677652.1 NZ_CP087805:205087-205422 [Moraxella bovis]
MMTYKGYVGEFTLDNDDEIFYGKLIGINQLVTFEADNAHDLKQAFYDSVDDYLAFCAEQGIEPDKPFKGSFNVRIDSELH
RRAYMASRDSSLNAFVGQAISEKLNRMAVSI

Download         Length: 336 bp

>AT226212 NZ_CP122318:c2482778-2482404 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References