Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 2281551..2282209 | Replicon | chromosome |
| Accession | NZ_CP087803 | ||
| Organism | Moraxella bovis strain SAM57947 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | LP097_RS11815 | Protein ID | WP_078274940.1 |
| Coordinates | 2282021..2282209 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | LP097_RS11810 | Protein ID | WP_112741846.1 |
| Coordinates | 2281551..2281958 (-) | Length | 136 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LP097_RS11780 (LP097_11665) | 2276782..2278611 | - | 1830 | WP_078274936.1 | hypothetical protein | - |
| LP097_RS11785 (LP097_11670) | 2278599..2278943 | - | 345 | WP_078274937.1 | hypothetical protein | - |
| LP097_RS11790 (LP097_11675) | 2278944..2279750 | - | 807 | WP_264684230.1 | hypothetical protein | - |
| LP097_RS11795 (LP097_11680) | 2279804..2280241 | - | 438 | WP_162860346.1 | hypothetical protein | - |
| LP097_RS11800 (LP097_11685) | 2280175..2280507 | - | 333 | WP_112741848.1 | hypothetical protein | - |
| LP097_RS11805 (LP097_11690) | 2280504..2281475 | - | 972 | WP_112741847.1 | phage tail tape measure protein | - |
| LP097_RS11810 (LP097_11695) | 2281551..2281958 | - | 408 | WP_112741846.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| LP097_RS11815 (LP097_11700) | 2282021..2282209 | - | 189 | WP_078274940.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| LP097_RS11820 (LP097_11705) | 2282352..2282567 | - | 216 | WP_078274941.1 | hypothetical protein | - |
| LP097_RS11825 (LP097_11710) | 2282569..2283168 | - | 600 | WP_078274942.1 | antA/AntB antirepressor family protein | - |
| LP097_RS11830 (LP097_11715) | 2283275..2283481 | - | 207 | WP_264676102.1 | DNA-binding protein | - |
| LP097_RS11835 (LP097_11720) | 2283604..2283948 | + | 345 | WP_264688874.1 | helix-turn-helix transcriptional regulator | - |
| LP097_RS11840 (LP097_11725) | 2283992..2284744 | - | 753 | WP_078274945.1 | hypothetical protein | - |
| LP097_RS11845 (LP097_11730) | 2284822..2285022 | - | 201 | WP_264676324.1 | hypothetical protein | - |
| LP097_RS11850 (LP097_11735) | 2285031..2285222 | - | 192 | WP_264676101.1 | DNA-binding protein | - |
| LP097_RS11855 (LP097_11740) | 2285237..2285446 | - | 210 | WP_264688815.1 | DNA-binding protein | - |
| LP097_RS11860 (LP097_11745) | 2285611..2285910 | + | 300 | WP_078274961.1 | helix-turn-helix transcriptional regulator | - |
| LP097_RS11865 (LP097_11750) | 2286105..2286392 | + | 288 | WP_078274962.1 | ORF6C domain-containing protein | - |
| LP097_RS11870 (LP097_11755) | 2286412..2286807 | + | 396 | WP_264696776.1 | S24 family peptidase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2272314..2300132 | 27818 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7047.13 Da Isoelectric Point: 10.3659
>T226211 WP_078274940.1 NZ_CP087803:c2282209-2282021 [Moraxella bovis]
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD
MPPSSDEMIKRITEDGWYFVKQKGSHKHYKHPTKEGKVTIPNGRENLPKGTLKSIIKQAGLD
Download Length: 189 bp
>T226211 NZ_CP122318:c2265628-2265287 [Escherichia coli]
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA
Antitoxin
Download Length: 136 a.a. Molecular weight: 14756.85 Da Isoelectric Point: 4.2244
>AT226211 WP_112741846.1 NZ_CP087803:c2281958-2281551 [Moraxella bovis]
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG
MLFPIAIEKPANENECYGVIVPDIAGCFSAGDTPDEAIKNAYEAISLHLEGMAEDGDTLPTAKPIFYHQDNSEFDGMLWA
VVDVDMSAFMGKAEKINVTLPSLLITKIDEKVLSHKSLYKSRSNYLAQLAMADLG
Download Length: 408 bp
>AT226211 NZ_CP122318:c2265966-2265649 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|