Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2121196..2121845 Replicon chromosome
Accession NZ_CP087803
Organism Moraxella bovis strain SAM57947

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LP097_RS11005 Protein ID WP_078274052.1
Coordinates 2121196..2121597 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LP097_RS11010 Protein ID WP_112741908.1
Coordinates 2121612..2121845 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP097_RS10970 (LP097_10855) 2116852..2117085 + 234 WP_112741910.1 ASCH domain-containing protein -
LP097_RS10975 (LP097_10860) 2117104..2117280 + 177 WP_228157829.1 ASCH domain-containing protein -
LP097_RS10980 (LP097_10865) 2117277..2117696 + 420 WP_078274047.1 S4 domain-containing protein -
LP097_RS10990 (LP097_10875) 2118432..2119121 + 690 WP_078274049.1 SIMPL domain-containing protein -
LP097_RS10995 (LP097_10880) 2119220..2120050 - 831 WP_078274050.1 inositol monophosphatase family protein -
LP097_RS11000 (LP097_10885) 2120172..2120672 - 501 WP_112741909.1 WG repeat-containing protein -
LP097_RS11005 (LP097_10890) 2121196..2121597 - 402 WP_078274052.1 type II toxin-antitoxin system VapC family toxin Toxin
LP097_RS11010 (LP097_10895) 2121612..2121845 - 234 WP_112741908.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LP097_RS11015 (LP097_10900) 2121893..2123992 - 2100 WP_078274054.1 1-deoxy-D-xylulose-5-phosphate synthase -
LP097_RS11020 (LP097_10905) 2124213..2124806 + 594 WP_208624078.1 GTP cyclohydrolase II -
LP097_RS11025 (LP097_10910) 2124826..2125818 + 993 WP_078274055.1 oxygen-dependent coproporphyrinogen oxidase -
LP097_RS11030 (LP097_10915) 2126000..2126449 + 450 WP_264676133.1 cytochrome c -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15131.33 Da        Isoelectric Point: 6.8510

>T226210 WP_078274052.1 NZ_CP087803:c2121597-2121196 [Moraxella bovis]
MFSFMLDTNIYIYVIKERPIKALNKFNQYAGRICVSSIVASELYFGAYNSQFMDKNLHQVEDFLSRLTVLDYTAECSPHY
GEICADLTKQGKLISENDIHIASHARALGLTLITNNTDEFKRVSGLRIGNWAI

Download         Length: 402 bp

>T226210 NZ_CP122318:2255036-2255434 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8990.22 Da        Isoelectric Point: 6.2884

>AT226210 WP_112741908.1 NZ_CP087803:c2121845-2121612 [Moraxella bovis]
MQTSVFFNNRTQAVRIPAKFRFDDDVKAVMIRKVGNERILTPIDGVWDSFFLSDERASDDFMANRPTMPKSERLTFD

Download         Length: 234 bp

>AT226210 NZ_CP122318:2254740-2255033 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References